Regions showing interaction between sex and BDNF Val66Met polymorphism on rCBF functional connectivity
| Seed/brain region | MNI coordinates | Cluster size | t values | P values | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Connectivity with BA25 | ||||||
| Val > Met (female > male) | ||||||
| R inferior frontal gyrus (BA45) | 36 | 22 | 8 | 66 | 3.80 | 0.0001 |
| R hippocampus | 34 | −42 | −2 | 21 | 3.70 | 0.0002 |
| L middle frontal gyrus (BA8) | −40 | 28 | 46 | 44 | 3.64 | 0.0002 |
| Ventral anterior cingulated (BA24) | 4 | −4 | 46 | 27 | 3.47 | 0.0004 |
| Connectivity with right hippocampus | ||||||
| Val > Met (female > male) | ||||||
| L DLPFC (BA9) | −54 | 14 | 34 | 470 | 4.69 | 0.000005* |
| L middle frontal gyrus (BA6) | −38 | 2 | 50 | 166 | 4.61 | 0.000007* |
| L middle frontal gyrus (BA10) | −22 | 56 | 22 | 212 | 4.59 | 0.000008* |
| L middle temporal gyrus (BA39) | −50 | −72 | 28 | 471 | 4.52 | 0.00001* |
| R DLPFC (BA9) | 56 | 12 | 38 | 184 | 4.29 | 0.00002 |
| R cingulate gyrus (BA29) | 8 | −48 | 8 | 98 | 4.23 | 0.00003 |
| R hippocampus | 30 | −16 | −20 | 29 | 4.19 | 0.00003 |
| R postcentral gyrus (BA4) | 18 | −36 | 74 | 300 | 4.18 | 0.00003 |
| R DLPFC (BA9) | 28 | 44 | 38 | 148 | 3.97 | 0.00007 |
| R precentral gyrus (BA4) | 24 | 20 | 58 | 161 | 3.97 | 0.00007 |
| R superior frontal gyrus (BA8) | 10 | 38 | 54 | 42 | 3.80 | 0.0001 |
| R cerebellum | 44 | −68 | −26 | 250 | 3.77 | 0.0002 |
| R postcentral gyrus (BA4) | 28 | −44 | 64 | 45 | 3.76 | 0.0002 |
| L middle frontal gyrus (BA10) | −26 | 64 | −4 | 87 | 3.72 | 0.0002 |
| R precentral gyrus (BA4) | 30 | −16 | 64 | 47 | 3.59 | 0.0003 |
| R parahippocampal gyrus (BA35) | 20 | −34 | −12 | 61 | 3.59 | 0.0003 |
| Dorsal anterior cingulate (BA32) | −4 | 32 | −10 | 45 | 3.58 | 0.0003 |
| L medial frontal gyrus (BA6) | −18 | −2 | 64 | 28 | 3.52 | 0.0003 |
| L postcentral gyrus (BA4) | −22 | −32 | 72 | 36 | 3.42 | 0.0005 |
| Connectivity with left parahippocampus | ||||||
| Val > Met (female > male) | ||||||
| L precentral gyrus (BA6) | −60 | −18 | 44 | 120 | 4.44 | 0.00001 |
| R fusiform gyrus (BA18) | 26 | −78 | −20 | 159 | 4.17 | 0.00004 |
| R precentral gyrus (BA8) | 8 | −26 | 74 | 96 | 3.99 | 0.00007 |
| L fusiform gyrus (BA18) | −28 | −86 | −22 | 111 | 3.77 | 0.0002 |
| R postcentral gyrus (BA4) | 58 | −20 | 54 | 17 | 3.72 | 0.0002 |
| R middle frontal gyrus (BA8) | 34 | 32 | 52 | 16 | 3.61 | 0.0003 |
| R ventral anterior cingulated (BA24) | 14 | −6 | 46 | 33 | 3.44 | 0.0003 |
| R middle temporal gyrus | 38 | 6 | −24 | 24 | 3.54 | 0.0003 |
| R parahippocampal gyrus | 32 | −48 | −6 | 18 | 3.51 | 0.0004 |
| L parahippocampal gyrus (BA28) | −24 | 4 | −22 | 13 | 3.36 | 0.0004 |
↵* FWE corrected at p < 0.05. Cluster size reported at p < 0.001. L, Left; R, right.