Negative associations between cumulative life stress and brain structure (greater cumulative life stress was related to smaller volumes)
| Region | Cluster size; corrected p value | Pearson's r value | Cluster coordinates (MNI space) |
|---|---|---|---|
| Right putamen | 249 voxels; p < 0.001 | r = −0.525 | +28, +7, +0 |
| Left putamen | 62 voxels; p = 0.016 | r = −0.377 | −21, +11, +1 |
| Right occipital lobe | 233 voxels; p < 0.001 | r = −0.419 | +30, −88, −13 |
| Right occipital lobe | 72 voxels; p = 0.007 | r = −0.439 | +9, −88, −4 |
| Left occipital lobe | 65 voxels; p = 0.013 | r = −0.456 | −8, −96, −18 |
| Right middle temporal gyrus | 175 voxels; p < 0.001 | r = −0.418 | +52, −11, −12 |
| Left middle temporal gyrus | 151 voxels; p < 0.001 | r = −0.469 | −62, −17, −7 |
| Right parietal white matter | 109 voxels; p < 0.001 | r = −0.429 | +32, −27, +33 |
| Right middle parietal gyrus | 67 voxels; p = 0.011 | r = −0.411 | +59, −42, +9 |
| Right precuneus | 137 voxels; p = 0.001 | r = −0.438 | +8, −58, +14 |
| Right cerebellum | 137 voxels; p < 0.001 | r = −0.415 | +41, −67, −22 |
| Ventral medial PFC | 189 voxels; p < 0.001 | r = −0.418 | +0, +23, −24 |
| Right prefrontal white matter | 121 voxels; p < 0.001 | r = −0.417 | +18, +38, +1 |
| Right frontal white matter | 87 voxels; p = 0.002 | r = −0.461 | +18, −12, +42 |
| Left frontal pole | 98 voxels; p < 0.001 | r = −0.422 | −20, +62, −9 |
| Left anterior cingulate | 50 voxels; p = 0.043 | r = −0.424 | −11, +45, +17 |
No positive associations with cumulative life stress and brain structure survived correction for multiple comparisons. All regions noted significant at p < 0.05 corrected for multiple comparisons, initial statistical threshold p = 0.0001 uncorrected.