Table 2.

JNPL3 tau mouse, SW control mouse, human control, and human AD brain quantification of tau and SG inclusions and colocalization of tau and SG pathology (±SD)

TissueDensity of SG/ 63× fieldAverage area of SG inclusions (TIA1+) (μm2)% Colocalization of Tau (PHF1+) with SGAverage degree of colocalization
Mouse
    SW control0.9 ± 0.72.7 ± 0.7n/an/a
    Tg normal3.0 ± 0.82.7 ± 0.9n/an/a
    Tg mild3.7 ± 0.72.8 ± 1.111.1 ± 11.70.692 ± 0.079
    Tg moderate8.7 ± 0.95.0 ± 2.345.4 ± 8.80.778 ± 0.084
    Tg severe22.2 ± 2.58.4 ± 3.869.1 ± 8.70.824 ± 0.098
Human
    Control0.9 ± 0.54.3 ± 1.81.1 ± 0.60.387 ± 0.172
    Alzheimer's29.1 ± 3.29.5 ± 3.064.2 ± 6.60.840 ± 0.069
  • The term Tg Normal refers to the age of 2 months, when no tau pathology is present.