Table 5.

Intrinsic membrane properties of newborn granule cells

dpiWTα2-FLt testMW testDunn's test
Cm (pF)712.09 ± 1.42 n = 1311.40 ± 0.89 n = 160.67270.8608NS
1413.70 ± 0.86 n = 1712.49 ± 0.80 n = 160.31480.3219NS
3010.70 ± 0.74 n = 1711.86 ± 0.85 n = 190.31880.2347NS
9010.07 ± 0.91 n = 159.07 ± 0.61 n = 210.34870.4703NS
    One-way ANOVAp = 0.06p = 0.0099
14 versus 90*
Rm (GΩ)71.37 ± 0.14 n = 131.80 ± 0.28 n = 140.19920.6979NS
140.79 ± 0.09 n = 160.76 ± 0.071 n = 160.85360.8358NS
300.73 ± 0.10 n = 160.80 ± 0.12 n = 170.68230.8712NS
900.67 ± 0.08 n = 140.90 ± 0.10 n = 160.07750.0504NS
    One-way ANOVAp = 0.006p = 0.0026
7 versus 14*; 7 versus 30**; 7 versus 90**7 versus 14**; 7 versus 30**
iNa+ (pA/pF)787.08 ± 18.49 n = 1293.68 ± 13.96 n = 160.77340.6260NS
14141.0 ± 14.32 n = 17146.1 ± 12.47 n = 160.78930.6787NS
30179.2 ± 15.36 n = 17168.4 ± 18.59 n = 190.66100.4661NS
90174.6 ± 21.65 n = 11158.5 ± 22.92 n = 170.63380.5409NS
    One-way ANOVAp = 0.0036p = 0.0192
7 versus 30**; 7 versus 90*7 versus 30*
  • Cm, Membrane capacitance; Rm, membrane resistance; iNa+, density of voltage-dependant Na+ channels-mediated currents (normalized to Cm). Values are mean ± SEM. General statistics are presented in Table 3. Each genotype was analyzed by one-way ANOVA, followed by Dunn's post hoc test (NS, p > 0.05;

  • *p < 0.05;

  • **p < 0.01;

  • ***p < 0.001). For a given time point, WT and α2-FL groups were compared two-by-two by Student's t test and Mann–Whitney U test (MW).