dpi | WT | α2-FL | t test | MW test | Dunn's test | |
---|---|---|---|---|---|---|
Cm (pF) | 7 | 12.09 ± 1.42 n = 13 | 11.40 ± 0.89 n = 16 | 0.6727 | 0.8608 | NS |
14 | 13.70 ± 0.86 n = 17 | 12.49 ± 0.80 n = 16 | 0.3148 | 0.3219 | NS | |
30 | 10.70 ± 0.74 n = 17 | 11.86 ± 0.85 n = 19 | 0.3188 | 0.2347 | NS | |
90 | 10.07 ± 0.91 n = 15 | 9.07 ± 0.61 n = 21 | 0.3487 | 0.4703 | NS | |
One-way ANOVA | p = 0.06 | p = 0.0099 | ||||
14 versus 90* | ||||||
Rm (GΩ) | 7 | 1.37 ± 0.14 n = 13 | 1.80 ± 0.28 n = 14 | 0.1992 | 0.6979 | NS |
14 | 0.79 ± 0.09 n = 16 | 0.76 ± 0.071 n = 16 | 0.8536 | 0.8358 | NS | |
30 | 0.73 ± 0.10 n = 16 | 0.80 ± 0.12 n = 17 | 0.6823 | 0.8712 | NS | |
90 | 0.67 ± 0.08 n = 14 | 0.90 ± 0.10 n = 16 | 0.0775 | 0.0504 | NS | |
One-way ANOVA | p = 0.006 | p = 0.0026 | ||||
7 versus 14*; 7 versus 30**; 7 versus 90** | 7 versus 14**; 7 versus 30** | |||||
iNa+ (pA/pF) | 7 | 87.08 ± 18.49 n = 12 | 93.68 ± 13.96 n = 16 | 0.7734 | 0.6260 | NS |
14 | 141.0 ± 14.32 n = 17 | 146.1 ± 12.47 n = 16 | 0.7893 | 0.6787 | NS | |
30 | 179.2 ± 15.36 n = 17 | 168.4 ± 18.59 n = 19 | 0.6610 | 0.4661 | NS | |
90 | 174.6 ± 21.65 n = 11 | 158.5 ± 22.92 n = 17 | 0.6338 | 0.5409 | NS | |
One-way ANOVA | p = 0.0036 | p = 0.0192 | ||||
7 versus 30**; 7 versus 90* | 7 versus 30* |
Cm, Membrane capacitance; Rm, membrane resistance; iNa+, density of voltage-dependant Na+ channels-mediated currents (normalized to Cm). Values are mean ± SEM. General statistics are presented in Table 3. Each genotype was analyzed by one-way ANOVA, followed by Dunn's post hoc test (NS, p > 0.05;
↵*p < 0.05;
↵**p < 0.01;
***p < 0.001). For a given time point, WT and α2-FL groups were compared two-by-two by Student's t test and Mann–Whitney U test (MW).