Table 1.

Passive membrane and action potential properties of Pten-cre neurons

Glutamatergic neuronsGABAergic neurons
Control (n = 21)Pten-cre (n = 22)Control (n = 23)Pten-cre (n = 24)
Vrest (in mV)−56 ± 2.1−58.1 ± 2.2−51.7 ± 2.1−56.1 ± 2.4
Rinput (in MΩ)438 ± 44356 ± 42618 ± 85551 ± 47
Time constant (in ms)23.2 ± 2.822.7 ± 1.933.3 ± 5.241.1 ± 4.3
Cm (in pF)59.8 ± 4.672.8 ± 6.5*53.3 ± 5.976.0 ± 6.2**
AP threshold (in mV)−29.2 ± 1.1−30.7 ± 2.1−33.4 ± 1.5−32.6 ± 1.1
AP amplitude (in mV)93.2 ± 3.282.9 ± 5.279.5 ± 2.576.2 ± 2.7
AP half-width (in ms)1.12 ± 0.051.48 ± 0.13*1.49 ± 0.071.77 ± 0.11*
AP rise max slope (in mV/ms)212 ± 14161 ± 21116 ± 8100 ± 9
AP fall max slope (in mV/ms)−89 ± 6−69 ± 8−60 ± 5−49 ± 5
AHP amplitude (in mV)−21.4 ± 1.7−19.4 ± 1.9−13.7 ± 1.9−14.1 ± 1.7
  • Measurements are shown as mean ± SEM.

  • *p ≤ 0.05;

  • **p ≤ 0.01 compared to control with unpaired t test or Mann–Whitney test.