Table 1.

Regulation of selected genes by GFAP/IKK2-CA in forebrain tissue at P7 and in primary astrocytes

Gene	Microarray (forebrain P7) Fold change	qPCR primary astrocytes (relative expression vs HPRT)^{^a}
Gene	Microarray (forebrain P7) Fold change	Co	IKK2-CA	Fold change	p value
Chemokines
Ccl5	24.44	0.107 ± 0.050	12.468 ± 14.911	116.9	0.0025
Cxcl10	20.84	1.255 ± 0.379	17.196 ± 17.847	13.7	0.0025
Ccl2	7.52	0.214 ± 0.079	4.907 ± 3.582	23.0	0.0025
Complement factors
C3	19.04	0.489 ± 0.412	14.131 ± 13.110	28.9	0.0051
C4b	3.13	0.057 ± 0.052	0.138 ± 0.104	2.4	0.15
C1s	3.02	0.355 ± 0.132	0.552 ± 0.313	1.6	0.43
Cell adhesion molecules
Madcam1	3.84	0.005 ± 0.004	0.408 ± 0.496	76.1	0.0025
Icam1	2.17	0.258 ± 0.033	0.950 ± 0.215	3.7	0.048
Other genes
Lcn2	59.48	0.123 ± 0.063	2.568 ± 2.770	20.8	0.0025
Cd74	14.96	0.010 ± 0.002	0.157 ± 0.052	15.1	0.0025
Tnf	1.00	0.070 ± 0.045	0.072 ± 0.059	1.0	0.88
Il1b	0.94	0.015 ± 0.012	0.013 ± 0.012	0.9	0.81
Celsr2	0.94	ND	ND	ND	ND
Foxj1	1.05	ND	ND	ND	ND
Myo9a	1.05	ND	ND	ND	ND