Protein antibody microarray
| Increased EXT versus FC-No EXT | Fold change | Decreased EXT versus FC-No EXT | Fold change |
|---|---|---|---|
| PRMT4 | 2.03 | p300/CBP | 0.679 |
| PRMT6 | 2.00 | HDAC2 | 0.673 |
| DNMT1 | 1.98 | NTF2 | 0.668 |
| Sp1 | 1.92 | HDAC5 | 0.649 |
| HAT1 | 1.88 | hBrm/hsnf2a | 0.630 |
| AP-1/c-Jun | 1.86 | Importin alpha5/7 | 0.618 |
| AP-2a | 1.85 | LAP2 (TMPO) | 0.595 |
| GATA-1 | 1.83 | Phospho-histone H3 (pSer10) | 0.581 |
| Phospho-histone H3 (pSer28) | 1.79 | Actin | 0.580 |
| ATF-2 | 1.75 | TRF-1 | 0.555 |
| p63 | 1.74 | H3K9me2 | 0.431 |
| MBD4 | 1.74 | PCNA | 0.311 |
| MeCP2 | 1.71 | Coilin | 0.279 |
| HDAC3 | 1.67 | ||
| bCATENIN (pSer33) | 1.66 | ||
| PCAF | 1.65 | ||
| HDAC10 | 1.64 | ||
| H3K9me | 1.60 | ||
| HDAC4 | 1.50 |
A direct comparison between fear-trained and extinction-trained mice revealed many epigenetic regulatory proteins that are preferentially associated with fear extinction.