Sox21 ChIP sequencing | Sox2 ChIP sequencing | ||||||||
---|---|---|---|---|---|---|---|---|---|
Accession No | Gene | Peak location | p | Overlap | Accession No | Gene | Peak location | p | Overlap |
NM_177753 | Sox21 | 0–5 kb down | 110.2 | + | NM_025434 | Mrps28 | Other intron | 76.5 | + |
NM_025434 | Mrps28 | Other intron | 82.2 | + | NM_177753 | Sox21 | 0–5 kb down | 66.1 | + |
NM_172990 | Pank4 | 10 k–5 kb up | 79.8 | + | NM_019514 | Trim32 | Other intron | 56.7 | − |
NM_010419 | Hes5 | 0–300 b up | 79.8 | + | NM_010308 | Gnao1 | Other intron | 52.8 | + |
NM_008972 | Ptma | 0–300 b up | 72.6 | − | NM_178642 | Tmem16a | Other intron | 50.8 | + |
NM_175274 | Ttyh3 | 10 k–5 kb down | 71.8 | + | NM_020296 | Rbms1 | Other intron | 50.3 | + |
NM_008494 | Lfng | 1st intron | 71.8 | + | NM_023049 | Asb2 | 10 k–5 kb down | 44.4 | + |
NM_027268 | Scrn1 | 1st intron | 70.2 | + | NM_010919 | Nkx2–2 | 1 k–5 kb up | 44.4 | − |
NM_001029850 | Magi1 | Other intron | 69.4 | + | NM_011137 | Pou2f1 | 1st intron | 44.4 | + |
NM_010439 | Hmgb1 | 0–300 b up | 66.9 | − | NM_021458 | Fzd3 | 1st intron | 42.4 | + |
NM_011319 | Sars | Other intron | 63.9 | + | NM_028778 | Nuak2 | 1st intron | 42.4 | + |
NM_010898 | Nf2 | 0–300 b up | 63.9 | − | NM_008952 | Pipox | 0–300 b up | 41.4 | + |
NM_011137 | Pou2f1 | 1st intron | 62.3 | + | NM_172913 | Tnrc9 | 0–5 kb down | 40.9 | − |
NM_011817 | Gadd45g | 0–300 b up | 62.3 | − | NM_007434 | Akt2 | Other intron | 39.5 | − |
NM_028778 | Nuak2 | 1st intron | 57.5 | + | NM_008494 | Lfng | 1st intron | 39.5 | + |
NM_001039484 | Kcnj10 | 1st intron | 55.9 | − | NM_175274 | Ttyh3 | 10 k–5 kb down | 39.5 | + |
NM_146057 | Dap | 0–300 b up | 55.1 | − | NM_183144 | Inpp5a | Other intron | 38.5 | + |
NM_029756 | Sdccag8 | 300–1 kb up | 54.3 | − | NM_001025074 | Ntrk2 | Other intron | 38.0 | + |
NM_201610 | Neil2 | 0–5 kb down | 54.3 | + | NM_027216 | Slc39a11 | Other intron | 38.0 | + |
NM_010308 | Gnao1 | Other intron | 54.3 | + | NM_028263 | Fgfbp3 | 10 k–5 kb down | 37.5 | − |
NM_010191 | Fdft1 | 0–300 b up | 54.3 | + | NM_201357 | Tssc1 | Other intron | 37.0 | + |
NM_008997 | Rab11b | 0–300 b up | 53.5 | − | NM_027268 | Scrn1 | 1st intron | 36.5 | + |
NM_201357 | Tssc1 | Other intron | 52.7 | + | NM_010097 | Sparcl1 | 1st intron | 36.0 | + |
NM_025980 | Nrarp | 0–300 b up | 52.7 | − | NM_011936 | Fto | 1st intron | 35.5 | − |
NM_013827 | Mtf2 | 0–300 b up | 51.9 | − | NM_172544 | Nrxn3 | Other intron | 35.5 | + |
NM_174988 | Cdh22 | Other intron | 51.1 | − | NM_007458 | Ap2a1 | 10 k–5 kb down | 34.5 | − |
NM_008629 | Msi1 | Other intron | 50.3 | − | BC057127 | Fuz | 10 k–5 kb up | 34.5 | − |
AK163963 | Gm1967 | 1st intron | 50.3 | + | NM_029365 | Med25 | 300–1 kb up | 34.5 | − |
NM_010913 | Nfya | 0–300 b up | 49.5 | − | NM_054043 | Msi2 | Other intron | 34.5 | + |
NM_009694 | Apobec2 | 10 k–5 kb down | 49.5 | − | NM_009846 | Cd24a | 1st intron | 33.5 | + |
NM_207219 | AI314976 | 0–300 b up | 49.5 | − | NM_016968 | Olig1 | 10 k–5 kb up | 33.5 | − |
NM_178642 | Tmem16a | Other intron | 48.7 | + | NM_011319 | Sars | Other intron | 33.5 | + |
NM_198247 | Sertad4 | 10 k–5 kb down | 48.7 | − | NM_178765 | 5730410E15Rik | Other intron | 33.0 | − |
NM_020296 | Rbms1 | Other intron | 48.7 | + | NM_010419 | Hes5 | 0–300 b up | 33.0 | + |
NM_054043 | Msi2 | Other intron | 48.7 | + | NM_027032 | Pacrg | Other intron | 33.0 | + |
NM_011544 | Tcf12 | Other intron | 47.9 | − | NM_172990 | Pank4 | 1 k–5 kb up | 33.0 | + |
NM_010952 | Oaz2 | 0–300 b up | 47.9 | − | NM_027504 | Prdm16 | Other intron | 33.0 | − |
NM_026201 | Ccar1 | 0–300 b up | 47.9 | − | NM_027539 | Dcamkl2 | Other intron | 32.6 | − |
NM_181585 | Pik3r3 | 300–1 kb up | 46.3 | − | NM_177618 | BC030477 | 1st intron | 31.6 | + |
NM_026272 | Narf | 0–300 b up | 46.3 | − | NM_172522 | Megf11 | Other intron | 31.6 | + |
NM_016701 | Nes | Other intron | 43.1 | + | NM_016701 | Nes | Other intron | 27.6 | + |
The 284 sites from the Sox21 ChIP sequencing data and the 301 sites from the Sox2 ChIP sequencing data were determined as described in Materials and Methods. Genes with these binding sites near their TSSs were annotated as bound genes and are shown here in decreasing order of maximum p values (−log10p). The top 40 genes and the Nestin gene are listed. The peak location is displayed relative to the genomic distance from the TSS. up, Upstream of TSS; down, downstream of TSS. If the peak resided within a coding region, the location is described as the 5′ UTR or introns. A plus sign in the Overlap column indicates that the gene in question was listed as both a Sox21 and Sox2 candidate target gene. The Nestin gene, which is expressed in NS/PCs, was bound by Sox2, consistent with a previous report showing that Sox2 binds to the second intron of the Nestin gene to modulate its expression (Zimmerman et al., 1994).