Table 1.

Results of the SHIRPA screen on HDC-Δγ2 and HDC-ΔB1 mice compared with littermate controls

Parameter measuredHDC-Δγ2 (n = 13)Littermate (n = 11)HDC-ΔB1 (n = 10)Littermate (n = 10)
Body position0000
Appearance0000
Whiskers0000
Tremor0000
Palpebral closure0000
Lacrimation0000
Defecation0000
Grooming0000
Transfer arousal0000
Locomotor activity0000
Gait0000
Stretch0000
Tail elevation0000
Startle responsenmnm00
Touch escape0000
Positional passivity0000
Trunk curl0000
Limb grasping0000
Pinna reflex0000
Corneal reflex0000
Contact righting reflex0000
Evidence of biting0000
Vocalization0000
Weight (g)34.31 ± 1.5)37.73 ± 0.929.9 ± 1.231.7 ± 2.0
  • nm, Not measured. There was also no difference in the weight of knockouts compared to littermates.