Nf1 genetically engineered mouse models of CNS dysfunction
| GEM strain | Description | CNS abnormality | References |
|---|---|---|---|
| Nf1+/− mice | Mice with reduced Nf1 gene expression throughout | Impaired learning, memory, and attention; increased astrogliosis | Jacks et al., 1994; Silva et al., 1997; Gutmann et al., 1999; Rizvi et al., 1999 |
| Nf1+/−Syn mice | Mice with reduced Nf1 gene expression in hippocampal neurons | Impaired learning, memory, and attention | Cui et al., 2008 |
| Nf1+/−GFAPCKO mice | Nf1+/− mice with complete Nf1 loss in neuroglial progenitors | Impaired learning, memory, and attention; optic glioma formation | Brown et al., 2010a; Bajenaru et al., 2003 |
| Nf1+/−; KRasGFAP mice | Nf1+/− mice with KRas activation in neuroglial progenitors | Optic glioma formation | Dasgupta et al., 2005a |
| Nf1;p53GFAPCKO mice | Mice with Nf1 and p53 inactivation in neuroglial progenitors | High-grade glioma formation | Zhu et al., 2005b |
| Nf1;p53; PtenGFAPCKO mice | Mice with Nf1,p53, and Pten inactivation in neuroglial progenitors | GBM formation | Kwon et al., 2008 |
| Nf1;p53; PtennestinCKO mice | Mice with Nf1,p53, and Pten inactivation in neural stem cells | GBM formation | Chen et al., 2012 |