Table 6.

Individual genes

Probe ID	Gene	TLG versus B	LG versus B	T versus B
Cytokines, chemokines		log₂ ratio	log₂ ratio	log₂ ratio
2777498	Il1b	2.40	1.84	NS
1243601	Il6 ^*(b)	3.84	2.03	NS
2630852	Il7	1.18	1.18	NS
1243862	Il11 ^*(b)	4.30	0.67	NS
2610234	Il15	2.79	2.96	NS
2792502	IL17d	−1.05	−0.66	−0.62
2711461	Tgfb1	0.49	NS	NS
2899863	Tnf	1.29	NS	NS
2690603	Spp1	2.94	NS	1.30
1245710	Ccl2 (Mcp1)	6.48	6.23	NS
1231814	Ccl5	7.25	7.40	NS
2835117	Ccl7	7.26	6.89	NS
1238886	Ccl8 ^*(b)	2.51	1.83	NS
2771766	Ccl12 ^*(b)	2.53	1.60	NS
2717015	Ccl17 ^*(d)	0.84	NS	NS
1238886	Ccl8	2.51	1.83	NS
2763245	Cxcl1	7.77	7.77	NS
1215862	Cxcl9	7.77	7.84	NS
3142803	Cxcl10	7.34	7.39	0.50
2658908	Cxcl12(SDF-1)	2.69	3.05	NS
2687586	Cxcl16	4.47	3.82	NS
Growth factors and related
3137287	Lif ^* (b)	2.29	0.53	NS
3105417	Bdnf	0.87	−0.49	1.05
2659994	Gdnf ^*(d)	0.99	NS	NS
2701233	Fgf1	−1.84	−1.87	NS
1239151	Fgf2	0.84	0.53	NS
1225565	Igf1 ^*(c)	0.92	NS	1.45
2937596	Ngfb	0.81	0.35	0.51
2618714	Pdgfb ^*(d)	2.28	NS	NS
2989955	Bmp1 ^*(d)	0.72	NS	NS
2659151	Thbs1 ^*(d)	1.23	NS	NS
2484527	Vegfa	0.41	NS	NS
Immune and inflammation-related receptors
2829008	Lifr	0.25	0.26	NS
3138904	Ntrk2 (TrkB)	−0.80	−0.66	NS
2602711	Tgfbr1	−0.23	−0.28	NS
2760979	Tgfbr2	NS	0.73	−0.61
2789239	Tgfbr3	−0.66	−0.51	−0.43
2733733	Tlr2	6.50	6.50	NS
2697002	Tlr3	2.48	2.53	NS
2752966	Tlr4	0.47	0.60	NS
2742075	CD14 ^*(b)	3.51	2.97	NS
2740852	F2r (Par1)	NS	−0.28	NS
2513826	Tnfrsf11b	3.38	2.12	1.52
1226099	Tnfsf13b ^*(b)	2.30	1.29	NS
3115796	CD40	6.07	5.60	NS
2589865	CD28 ^*(c)	NS	NS	0.47
Transcription factors and intracellular signaling molecules
1245579	Jak2	1.63	1.44	NS
2655721	Stat1	4.15	4.23	NS
2657822	Stat2	2.71	2.87	NS
3096144	Stat3	1.33	1.38	NS
2618176	Soc3	1.70	1.14	0.67
2938893	Smad3	1.30	1.41	NS
2706631	Smad4	−0.59	−0.55	NS
2971767	MyD88 ^*(b)	2.72	3.02	NS
2937735	Irak2	0.86	NS	0.98
2592476	Nfkb1	2.21	1.91	NS
2714534	Map2k1	1.07	0.71	NS
1245924	Map3k8	2.73	2.63	NS
2599782	Irf1	4.82	5.09	−0.35
2664319	Irf3	−0.21	NS	NS
		log₂ ratio	log₂ ratio	log₂ ratio
2621752	Irf5 ^*(b)	2.04	1.66	NS
2652857	Ifi47	6.37	6.37	NS
2604029	Klf2 ^*(b)	0.57	1.53	NS
1252078	Foxp1 ^*(d)	0.31	NS	NS
Extracellular matrix and cell–cell contact related
2699488	Lamb2	−0.71	−0.72	NS
2974798	Lamc1	0.95	1.08	NS
2775307	Lamc2	1.12	0.74	NS
2670486	Bcan	−1.04	−0.59	NS
2993652	Ncan	NS	−0.63	NS
1254975	Has2	1.67	1.31	NS
2864172	Chst3	0.67	NS	0.47
1216374	Chst7	0.92	0.97	NS
2643049	Chst8	−0.80	−1.34	1.14
1215528	Chst11	1.56	0.49	0.83
2862538	Col12a1	1.19	NS	NS
2599692	Colm (Gliomedin) ^*(a)	1.54	0.31	0.41
2697380	Notch3 ^*(a)	0.49	−0.35	1.36
2753809	Mmp3	2.74	1.85	NS
1215120	Sema4A ^*(b)	1.72	0.33	NS
2790357	Sema7a ^*(c)	0.47	NS	1.07
2670172	Itga5 ^*(d)	0.77	NS	NS
Inflammatory-related enzymes
1223499	Nos2 ^*(b)	2.53	1.28	NS
2650280	Sod2	1.42	1.57	NS
1241892	Sod3	1.06	0.66	NS
2786442	Ptges	1.60	1.97	NS
2997494	Lox ^*(c)	2.42	NS	1.32
Channels and connexins
2980661	Aqp1	0.21	NS	NS
2757232	Aqp4	NS	NS	NS
1214634	Aqp9 ^*(d)	−0.65	NS	NS
1225901	Aqp11	−0.73	−0.67	−0.45
1244291	Gja1 (Cx43)	−0.97	−1.11	NS
2691641	Gja5 (Cx40) ^*(b)	0.64	0.27	NS
2999627	Gjb2 (Cx26) ^*(b)	2.91	1.32	NS
2946088	Panx1	0.76	0.46	NS
2621548	TrpA1	NS	NS	NS
Transporters
3123195	Slc1a2 (Glt1)	NS	0.61	NS
2905589	Slc6a1 (Gat1)	−0.26	−0.26	NS
1212645	Slc6a13 (Gat3)	NS	NS	NS
2948143	Slc7a11 (xCT)	2.49	2.98	NS
Astrocyte-related molecules
2706906	Fthfd (Aldh1l1)	−0.65	−0.39	NS
2644496	Glul (Gln Synthetase)	−0.97	−0.70	NS
1214715	Gfap	NS	NS	NS
2634742	S100b	NS	NS	NS
2840213	Cryab	NS	NS	NS
2712075	Lcn2 (lipocalin2)	4.98	4.98	0.82
2697304	Eln (elastin) ^*(c)	1.81	NS	0.95

NS, nonsignificant by criteria of FDR > 0.05 or not within 0.20 log₂ change cutoff.
↵*, Synergistic interaction of TLG treatment and (a–d) = category of type of synergistic interaction as described in Table 2.