Table 3.

F values of RM-MANOVAs and post hoc analysis of each independent variable tested in the acquisition and cued sessions of the Morris water maze

SessionGenotypeTreatmentGenotype × treatment
Acquisition between sessions (S1–S8)
    RM-MANOVA genotype × treatmentF(7,38) = 18.71, p < 0.001F(1,38) = 26.91, p < 0.001F(1,38) = 10.68, p = 0.002F(1,38) = 10.83, p = 0.002
    Post hoc comparisons between each pair of learning curves
        Vehicle CO versus vehicle TSF(1,23) = 46.14, p < 0.001
        RO4938581 CO versus RO4938581 TSF(1,18) = 1.49, p = 0.24
        Vehicle TS versus RO4938581 TSF(1,23) = 31.33, p < 0.001
        Vehicle CO versus RO4938581 COF(1,22) = 0.00, p = 0.98
Acquisition (S9–S12)
    RM-MANOVA genotype × treatmentF(3,38) = 11.56, p = 0.002F(1,38) = 16.24, p < 0.001F(1,38) = 6.11, p = 0.020F(1,38) = 8.19, p = 0.008
    Post hoc comparisons between each pair of learning curves
        Vehicle CO versus vehicle TSF(1,23) = 15.04, p = 0.002
        RO4938581 CO versus RO4938581 TSF(1,18) = 1.98, p = 0.18
        Vehicle TS versus RO4938581 TSF(1,23) = 7.65, p = 0.018
        Vehicle CO versus RO4938581 COF(1,22) = 0.16, p = 0.69
Acquisition between trials
    RM-MANOVA genotype × trialTrial: F(7,38) = 6.04, p < 0.001F(1,42) = 35.62, p < 0.001F(1,38) = 14.59, p < 0.001F = 14.78, p < 0.001
    Post hoc comparisons between each pair of learning curves
        Vehicle CO versus vehicle TSF(1,23) = 50.67, p < 0.001
        RO4938581 CO versus RO4938581 TSF(1,18) = 2.28, p = 0.14
        Vehicle TS versus RO4938581 TSF(1,23) = 49.42, p < 0.001
        Vehicle CO versus RO4938581 COF(1,22) = 0.00, p = 0.99
Thigmotaxis
    (All sessions) RM-MANOVA genotype × treatmentF(11,38) = 13.92, p < 0.001F(1,38) = 20.73, p < 0.001F(1,38) = 7.82, p = 0.009F(1,38) = 1.89, p = 0.18
    S1–S12 post hoc comparisons RM-MANOVA session × group
        TS vehicle: F(11,9) = 1.09, p = 0.37
        CO vehicle: F(11,9) = 6.43, p < 0.001
        TS RO4938581: F(11,12) = 5.62, p < 0.001
        CO RO4938581: F(11,12) = 10.09, p < 0.001
    Mean of cued sessions MANOVA genotype × treatmentF(1,38) = 9.82, p = 0.004F(1,38) = 2.43, p = 0.13F(1,38) = 2.14, p = 0.15
Probe trial
    n of crossings over platform
        MANOVA genotype × treatmentF(1,38) = 9.27, p = 0.005F(1,38) = 1.21, p = 0.29F(1,38) = 0.43, p = 0.51
    n of entries in trained quadrant
        MANOVA genotype × treatmentF(1,38) = 10.41, p = 0.003F(1,38) = 5.24, p = 0.030F(1,38) = 0.69, p = 0.41
    Percentage of time in quadrants
        MANOVA quadrant × genotype × treatmentQuadrant: F(3,37) = 13.56, p = 0.001F(1,38) = 2.91, p = 0.021F(1,38) = 10.92, p = 0.002F(1,38) = 1.10, p = 0.30
Cues sessions
    Latency
        MANOVA genotype × treatment:treatmentF(1,38) = 3.93, p = 0.054F(1,38) = 8.58, p = 0.006F(1,38) = 5.76, p = 0.021
Speed
    MANOVA genotype × treatmentF(1,38) = 2.77, p = 0.10F(1,38) = 0.55, p = 0.46F(1,38) = 0.011, p = 0.91