Firing rates and response parameters to motor cortical stimulation of GP and SNr neurons before [IT(−)] and after [IT(+)] IT treatment in MG-IG mutant mice
| GP | SNr | |||
|---|---|---|---|---|
| IT(−) | IT(+) | IT(−) | IT(+) | |
| No. of neurons | 182 | 106 | 111 | 58 |
| Firing rate (Hz) | 60.96 ± 15.05 | 63.80 ± 11.98 | 57.07 ± 16.24 | 60.12 ± 14.34 |
| Mean of ISI (ms) | 17.58 ± 5.02 | 16.14 ± 3.01 | 19.04 ± 5.58 | 17.70 ± 4.80 |
| CV of ISI | 0.66 ± 0.18 | 0.62 ± 0.15 | 0.66 ± 0.20 | 0.61 ± 0.15 |
| No. of neurons | 127 | 63 | 55 | 22 |
| Early excitation | n = 114 | n = 57 | n = 49 | n = 18 |
| Latency (ms) | 3.22 ± 1.60 | 3.70 ± 1.52 | 4.86 ± 2.45 | 3.84 ± 1.46 |
| Duration (ms) | 5.17 ± 6.46 | 4.23 ± 1.95 | 8.02 ± 5.22 | 5.88 ± 2.63 |
| Amplitude (spikes) | 65.88 ± 43.38 | 54.19 ± 31.48 | 104.83 ± 77.61 | 83.93 ± 49.01 |
| Inhibition | n = 80 | n = 38 | n = 25 | n = 13 |
| Latency (ms) | 10.29 ± 3.02 | 9.41 ± 2.16 | 13.50 ± 6.05 | 13.12 ± 5.42 |
| Duration (ms) | 7.66 ± 6.26 | 7.00 ± 2.94 | 9.82 ± 7.41 | 8.84 ± 4.36 |
| Amplitude (spikes) | −43.36 ± 43.37 | −44.8 ± 24.6 | −50.69 ± 42.01 | −38.9 ± 22.12 |
| Late excitation | n = 92 | n = 49 | n = 32 | n = 15 |
| Latency (ms) | 17.28 ± 4.67 | 17.96 ± 1.94 | 20.27 ± 8.39 | 20.35 ± 5.96 |
| Duration (ms) | 17.40 ± 16.25 | 13.53 ± 13.60 | 7.37 ± 4.97 | 9.46 ± 5.25 |
| Amplitude (spikes) | 161.68 ± 191.32 | 114.87 ± 174.88 | 70.01 ± 61.52 | 82.27 ± 56.86 |
Values are mean ± SD. Neurons with significant early excitation, inhibition, and/or late excitation were used for calculation (n indicates number of neurons used).