Genotype | Values ± SEM (n) | Statistical test | p value |
---|---|---|---|
P9–P11 synapse | |||
eEPSC amplitude (nA) | |||
WT | 1.47 ± 0.13 (28) | Student's t test | p > 0.05 |
Munc13-2 KO | 1.25 ± 0.08 (23) | ||
WT | 1.57 ± 0.16 (17) | Student's t test | p > 0.05 |
Munc13-3 KO | 2.02 ± 0.20 (17) | ||
WT (a) | 1.88 ± 0.15 (19) | Kruskal–Wallis test* | p > 0.05 (a vs b) |
Munc13-2-3 DKO (b) | 2.00 ± 0.20 (18) | p < 0.0001 (b vs c) | |
Munc13-1(1–451) (c) | 0.59 ± 0.06 (18) | ||
Cumulative EPSC amplitude (nA) | |||
WT | 4.00 ± 0.34 (16) | Student's t test | p > 0.05 |
Munc13-2 KO | 4.07 ± 0.38 (11) | ||
WT | 4.40 ± 0.42 (12) | Student's t test | p > 0.05 |
Munc13-3 KO | 5.14 ± 0.53 (8) | ||
WT (a) | 6.32 ± 0.44 (15) | Kruskal–Wallis test* | p > 0.05 (a vs b) |
Munc13-2-3 DKO (b) | 6.15 ± 0.50 (17) | p < 0.0001 (b vs c) | |
Munc13-1(1–451) (c) | 2.72 ± 0.24 (16) | ||
P18–P21 synapse | |||
eEPSC amplitude (nA) | |||
WT | 4.94 ± 0.40 (21) | One-way ANOVA | p > 0.05 |
Munc13-2 KO | 5.78 ± 0.52 (23) | ||
Munc13-3 KO | 5.96 ± 0.71 (14) | ||
WT (a) | 5.29 ± 0.51 (24) | Kruskal–Wallis test* | p > 0.05 (a vs b) |
Munc13-2-3 DKO (b) | 5.80 ± 0.49 (24) | p < 0.01 (b vs c) | |
Munc13-1(1–451) (c) | 2.57 ± 0.32 (15) | ||
Cumulative EPSC amplitude (nA) | |||
WT | 20.08 ± 2.76 (16) | One-way ANOVA | p > 0.05 |
Munc13-2 KO | 20.64 ± 2.07 (18) | ||
Munc13-3 KO | 21.88 ± 2.65 (12) | ||
WT (a) | 26.48 ± 2.01 (22) | Kruskal–Wallis test* | p > 0.05 (a vs b) |
Munc13-2-3 DKO (b) | 25.97 ± 3.58 (20) | p < 0.001 (b vs c) | |
Munc13-1(1–451) (c) | 10.97 ± 1.26 (14) |
↵*Kruskal–Wallis test with a post hoc Dunn's test to compare selected pairs.