Action potential characterization for WT and mutant Nav1.8 channels in adult rat DRG neurons
| Nav1.8 | Spontaneously firing neurons | Repetitive firing neurons | Input resistance (GΩ) | Resting membrane potential (mV) | Action potential amplitude (mV) | Half-width (ms) | Voltage threshold (mV) | Current threshold (pA) |
|---|---|---|---|---|---|---|---|---|
| WT | 10 of 48, 21% | 24 of 38, 63% | 0.594 ± 0.086 | −51.1 ± 1.4 | 111 ± 2.5 | 8.89 ± 0.83 | −25.5 ± 1.2 | 139 ± 16 |
| I1706V | 14 of 53, 26% | 36 of 39, 92%* | 0.665 ± 0.10 | −45.8 ± 1.3* | 115 ± 2.5 | 7.92 ± 0.78 | −31.0 ± 0.91* | 66.0 ± 9.9* |
↵*p < 0.05 versus WT channels.