Table 2.

EPM activity and PPI in transgenic mice overexpressing human RCAN1^{^a}

Genotype	EPM					PPI
	Time in zone (s)			Dist (cm)	Vel (cm/s)	dB 120	Percentage inhibition (pre-dB)
	Closed	Open	Center	Dist (cm)	Vel (cm/s)	dB 120	Null	74	78	82	86	90
Nse-RCAN1^Tg1a
Mean	242.7	16.2	38.6	1121.3	3.8	590.5	48.2	20.4	44.2	52.8	64.1	71.8
SEM	4.2	2.4	2.2	49.2	0.2	92.3	4.1	14	11.1	11.3	10	8.2
WT-Tg1a (Nse)
Mean	224.9	29.3	43.9	1219.1	4.1	531.7	56.2	22.6	40.3	63.2	72.2	77.7
SEM	4.5	4.4	3.0	46.1	0.2	41.1	3.9	7.5	6.3	4.6	3.7	3.6
p value	0.003	0.044	0.093	0.110	0.154	0.509	0.208	0.693	0.695	0.516	0.419	0.454
Nse-RCAN1^Tg
Mean	212.9	34.0	53.1	993.6	3.2
SEM	18.6	12.2	15.3	95.3	0.3
WT-Tg1 (Nse)
Mean	189.9	44.1	44.6	1116.6	3.8
SEM	25.3	13.9	7.7	131.9	0.5
p value	0.843	0.905	0.501	0.453	0.271
CamkIIα-RCAN1^Tg1a
Mean	222	31.4	46.2	1231.1	4.2	563.8	51.8	15.7	33.9	53.8	67.2	71.8
SEM	8.9	6.8	4.4	67.5	0.2	93.3	4.4	9.1	7.6	5.4	6.1	5.5
WT-Tg1a (CamkIIα)
Mean	229.3	26.6	43.4	1241.9	4.2	706.8	50.6	27.9	41.5	55.8	70.7	80
SEM	5.8	4	4.7	60.8	0.2	91.4	10.1	17.7	9.9	5.5	6.3	5.1
p value	0.747	0.986	0.618	0.906	0.899	0.428	0.824	0.797	0.943	0.84	0.951	0.577
CamkIIα-RCAN1^Tg1
Mean	193.8	34.4	71.5	1344.6	4.5
SEM	10.3	8.7	8.2	57.7	0.2
WT-Tg1 (CamkIIα)
Mean	227.4	23	49.3	1350.2	4.6
SEM	9.4	5.6	7.3	74.8	0.3
p value	0.039	0.401	0.069	0.954	0.96

↵^aLeft columns show EPM performance. Nse-RCAN1^Tg1a mice show reduced open-arm time relative to controls while other manipulations of RCAN1 overexpression did not affect open-arm time. Right columns show normal PPI of the acoustic startle response in RCAN1-overexpressing transgenic lines tested. See Materials and Methods for detailed genotype description. Dist, Distance traveled; Vel, ambulatory velocity. PPI percentage inhibition based on inhibition compared to the startle response to intertrial pulses.