Control | CIH | |||||||
---|---|---|---|---|---|---|---|---|
Group I (n = 9) | Group II (n = 12) | Group III (n = 12) | Group IV (n = 12) | Group I (n = 10) | Group II (n = 12) | Group III (n = 14) | Group IV (n = 10) | |
Capacitance (pF) | 39 ± 1.9 | 36 ± 1.7 | 40 ± 1.8 | 42 ± 1.8 | 40 ± 3.6 | 41.5 ± 2.8 | 38 ± 2.7 | 40 ± 1.2 |
Frequency (Hz) | 6 ± 1.1 | 22 ± 3* | 13 ± 2 | 8 ± 1.9 | 6.4 ± 2.2 | 20 ± 2.4 | 15 ± 3.1 | 9 ± 2 |
RMP (mV) | −53 ± 2.2 | −51 ± 2.3 | −52 ± 3.2 | −54 ± 3.4 | −52 ± 4 | −50 ± 2 | −53 ± 2.1 | −53 ± 2 |
Ri (MΩ) | 335 ± 1.1** | 162 ± 6.5# | 245 ± 5## | 515 ± 9 | 348 ± 8 | 159 ± 7 | 259 ± 5 | 509 ± 16.6 |
Excitability (spikes) | 46 ± 6** | 90 ± 8.7+ | 61 ± 7 | 64 ± 6 | 49 ± 6 | 95 ± 7.7 | 59 ± 6.7 | 74 ± 5 |
AHP (mV) | 7 ± 1.1### | 3 ± 0.6 | 3.3 ± 0.7 | 6 ± 1.3 | 7.2 ± 2.2 | 2.8 ± 0.9 | 3 ± 0.9 | 6.2 ± 2.3 |
Excitability: values in response to injection of 100 pA of positive current.
↵*p < 0.05 different in relation to groups I, III, and IV from control rats;
↵**p < 0.001 different in relation to the groups II, III, and IV from control rats;
↵#p < 0.001 different in relation to the groups III and IV from control rats;
↵##p < 0.001 different in relation to the group IV from control rats;
↵###p < 0.05 different in relation to the groups II and III from control rats;
↵+p < 0.05 different in relation to the group III from control rats. CIH produced no changes in the electrophysiological properties of the 4 groups of RVLM presympathetic neurons characterized, and the differences among the groups in CIH were also similar to those observed in neurons from control rats.