Table 2.

eIL-1R1KD attenuated RSD-induced inflammatory gene expression in enriched brain CD11b+ cells

GeneWTeIL-1R1kd
CONRSDCONRSD
IL-1β1.02 ± 0.094.37 ± 1.08*,‡1.28 ± 0.362.19 ± 0.37*
TNF-α1.03 ± 0.113.19 ± 1.04*1.24 ± 0.371.21 ± 0.32
IL-61.19 ± 0.314.01 ± 1.88*,‡1.86 ± 0.641.27 ± 0.22
CCL21.03 ± 0.0911.30 ± 4.93*,‡1.57 ± 0.402.59 ± 0.74
CD141.03 ± 0.114.18 ± 1.80*1.10 ± 0.312.08 ± 0.47
CX3CR11.00 ± 0.030.74 ± 0.10#1.09 ± 0.210.72 ± 0.11#

  • WT and eIL-1R1kd FVB mice were subjected to RSD or left undisturbed as CON mice. Enriched brain CD11b+ cells were collected, and relative mRNA expression of IL-1β, TNF-α, IL-6, CCL2, CD14, and CX3CR1 is shown. Values represent average ± SEM.

  • ↵*p < 0.05, significantly different from WT–CON;

  • ↵#p < 0.10, different from WT–CON;

  • ↵‡p < 0.05, significantly different from eIL-1R1kd–CON.