Table 3.

Significant differences in gray matter density between marijuana users (MJ) and healthy controls (CON): whole-brain analysis

Area	Region	Hemisphere	x	y	z	Peak z	Volume, mm³
MJ > CON
Frontal	Middle frontal gyrus	R	30	−10	44	3.71	48
Parietal	Precuneus	R	24	−60	26	4.16	472
Parietal	Postcentral gyrus	L	−24	−36	58	3.75	184
Temporal	Insula	L	−30	14	2	3.63	80
Subcortical	Nucleus accumbens/putamen	L	−12	2	−10	4.19	296
Subcortical	Amygdala	L	−24	−12	−8	3.56	40
Occipital	Lateral occipital cortex	R	36	−76	30	3.69	48
	Occipital cortex	L	−20	−78	26	3.73	56
CON > MJ
Frontal	Frontal pole	R	32	54	6	3.94	760
	Dorsolateral prefrontal cortex	R	36	−16	48	3.94	448
	Middle frontal gyrus	R	30	20	58	3.67	80
	Frontal pole	L	−20	68	−6	4.62	40
Temporal	Temporal pole	L	−32	8	−48	4.42	312
Temporal	Superior temporal gyrus	L	−48	−6	−12	3.60	88
Occipital	Lateral occipital cortex	R	8	−66	66	3.77	72

All clusters were derived from a VBM analysis. Significant clusters consisted of at 40 mm³ (5 voxels) thresholded at z = 3.3 (p < 0.001), with a peak voxel of z > 3.5 (p < 0.0005). Coordinates are in MNI space and are listed in millimeters.