Sexual behaviors affected by inflammatory pain in female mice in the paced mating (F-PM) paradigm
| Condition | n | Mount - I (no.) | Mount + I (no.) | Ejac. (no.) | 1st Mount (s) | III (s) | ID (s) | M/I (no.) | Crossings (s) | Male side (s) | Return (s) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| No treatment | 13 | 7.0 (2.1) | 33.5 (3.9) | 0.4 (0.1) | 609 (178) | 70 (10) | 12 (2) | 0.8 (0.04) | 43.4 (13.6) | 1962 (222) | 159 (61) |
| Saline-vulva | 8 | 5.1 (1.4) | 24.4 (3.1) | 0.5 (0.2) | 1020 (238) | 79 (7) | 13 (1) | 0.8 (0.03) | 38.6 (8.4) | 1611 (317) | 210 (119) |
| Saline-hind paw | 9 | 4.4 (1.3) | 32.3 (4.7) | 0.7 (0.2) | 293 (120) | 75 (12) | 12 (1) | 0.9 (0.04) | 41.0 (15.2) | 2090 (333) | 60 (19) |
| Saline-tail | 7 | 10.1 (3.4) | 33.6 (6.3) | 0.3 (0.2) | 428 (175) | 60 (6) | 15 (3) | 0.8 (0.06) | 27.3 (11.2) | 1905 (302) | 90 (29) |
| Saline-cheek | 7 | 12.1 (2.5) | 42.0 (8.3) | 0.3 (0.2) | 1245 (218) | 34 (7) | 9 (1) | 0.7 (0.11) | 14.0 (7.2) | 2721 (426) | 31 (20) |
| No pain | 44 | 7.5 (1.0) | 32.8 (2.3) | 0.4 (0.1) | 691 (96) | 65 (5) | 12 (1) | 0.8 (0.02) | 34.8 (5.7) | 2036 (141) | 115 (31) |
| ZYM-vulva (Genital pain) | 8 | 1.8 (0.4)** | 16.0 (2.8)** | 0.2 (0.2) | 765 (450) | 112 (26) | 22 (4)** | 0.9 (0.02) | 41.0 (15.1) | 1254 (375)* | 211 (114) |
| ZYM-hind paw | 8 | 2.9 (0.8) | 18.2 (4.5) | 0.1 (0.1) | 1076 (315) | 133 (36) | 12 (1) | 0.9 (0.05) | 30.1 (11.4) | 1430 (397) | 392 (117) |
| CARR-tail | 7 | 2.9 (1.1) | 12.0 (6.2) | 0.6 (0.2) | 582 (147) | 137 (58) | 17 (5) | 0.6 (0.14) | 40.6 (15.5) | 1025 (272) | 109 (39) |
| CARR-cheek | 8 | 0.9 (0.6) | 5.8 (2.3) | 0 (0) | 602 (400) | 78 (34) | 7 (3) | 0.4 (0.19) | 15.4 (4.8) | 686 (191) | 377 (144) |
| Nongenital pain | 23 | 2.2 (0.5)** | 12.0 (2.7)** | 0.2 (0.1) | 761 (181) | 116 (25)* | 12 (2) | 0.6 (0.08)* | 28.4 (6.5) | 1048 (179)** | 290 (68)* |
Values represent mean (SEM). Mount - I, Frequency of mounts (defined as direct genital contact by the male onto flanks of the female without achieving penetration, often accompanied by female lordosis) without intromission; Mount + I, frequency mounts with intromission (defined as two or more distinct thrusts with penetration); Ejac., ejaculation frequency; 1st Mount, latency to first mount (with or without intromission); III, average inter-intromission interval; ID, average intromission duration; M/I, ratio of mounts to intromissions; Crossings, number of entries/exits into the male side; Male side, total time spent on male side; Return, average latency to return to the male side following intromission; CARR, carrageenan; ZYM, zymosan.
↵*p < 0.05 compared with No Pain;
↵**p < 0.01 compared with No Pain. ANOVAs were followed by Dunnett's case-comparison posthoc test with No Pain as the comparator group.