Table 2.

Potential CREB target genes differentially expressed in the hippocampus of trained APP_Sw,Ind

Biological pathway/gene	Gene	GenBank	Log fold-change	p	Biological function
Metabolism
Lactate dehydrogenase A	Ldha	NM_010699	−5.08	0.0001	Conversion of L-lactate to pyruvate
ATP synthase subunit c1	Atp5g1	NM_007506	−4.00	0.001	ATP synthesis
Glu oxaloacet transaminase1	Got1	NM_010324	−3.71	0.001	Aspartate aminotransferase activity
Enolase 2/γ-enolase	Eno2	NM_013509	−3.03	0.028	Glycolysis
Na⁺/K + ATPase α1	Atp1a1	NM_144900	−2.37	0.01	Na⁺/K⁺ transport, ATP synthesis
Isopentenyl-diphosphate δ-isomer1	Idi1	NM_145360	−1.86	0.008	Isoprenoid biosynthetic pathway
Solute carrier family 38	Slc38a1	NM_134086	−1.38	0.011	Glutamine transporter
Uncoupling protein 2	Ucp2	NM_011671	−1.12	0.041	Mitochondria proton uncoupling
Pyruvate dehydrogenase kinase 4	Pdk4	NM_013743	1.78	0.019	Pyruvate metabolism
N(α)-acetyltransferase 50	Naa50	NM_028108	1.12	0.025	Acetyltransferase activity
Neurotransmission, plasticity, ves traff
Neuritin/cpg 15	Nrn1	NM_153529	−4.34	0.001	Neuritogenesis, synaptic plasticity
Secretogranin II	Scg2	NM_009129	−3.76	0.007	Vesicle release, neuromodulation
Glutamate receptor GluA1	Gria1	NM_008165	−3.00	0.005	Neurotransmission, memory
Syntaxin 4A	Stx4a	NM_009294	−2.28	0.004	Docking of synaptic vesicles
Synaptotagmin IV	Syt4	NM_009308	−1.99	0.004	Exocitosis of synaptic vesicles
Chromogranin A	Chga	NM_007693	−1.50	0.033	Vesicle release, neuromodulation
RAB2A	Rab2a	NM_021518	−1.42	0.002	Protein transport from ER to Golgi
Syntaxin 18	Stx18	NM_026959	−1.40	0.042	SNAP receptor
Leucin rich repeat TM Neuronal 1	Lrtm1	NM_028880	−1.36	0.049	Synapse formation, axon traficking
Cell adhesion/cytoskeleton
Claudin 5	Cldn5	NM_013805	−2.92	0.02	Component of tigh junctions
Neurofilament, light peptide	Nefl	NM_010910	−2.60	0.0001	Neurofilament member
Fibronectin 1	Fn1	NM_010233	−2.38	0.042	Cell adhesion and migration
Brain angiogenesis inh 1-ass.prot 2	Baiap2	NM_130862	−2.25	0.01	Actin cytoskeleton, neuritogenesis
Angio-associated migratory protein	Aamp	NM_146110	−1.69	0.003	Cell migration
Chondroitin sulfate proteoglycan 5	Cspg5	NM_013884	−1.64	0.013	Dendritic branching and synapses
Calsyntenin 3	Clstn3	NM_153508	−1.46	0.005	Cell adhesion, associative learning
Myelin oligodendrocyte glycoprotein	Mog	NM_010814	−1.18	0.002	Maintenance myelin sheath
Neurocan	Ncan	NM_007789	1.14	0.03	Neuronal adhesion, neurite growth
Cell signaling
Protein phosph 1, reg sub 11	Ppp1r11	NM_029632	−2.29	0.02	Inhibitor of PP1
TrkB	Ntrk2	NM_008745	−2.16	0.02	BDNF, NT-3/4/5 receptor
P tyrosine phosphatase 4a1	Ptp4a1	NM_011200	−2.15	0.03	Protein tyrosine phosphatase
Transducer of ErbB-2.1	Tob1	NM_009427	−1.93	0.02	Antiproliferation, learning/memory
Regulator of G-protein signaling 4	Rgs4	NM_009062	−1.83	0.02	Regulates GTPase activity
Cyclin-dependent kinase 5	Cdk5	NM_007668	−1.32	0.002	Neurodegen., associative memory
Disabled homolog1	Dab1	NM_010014	−1.13	0.03	Adapter molecule, neural develop.
Cyclin-dependent kinase 16	Cdk16	NM_011049	−1.09	0.03	Neurite outgrowth, neuron migration
Transcriptional regulation
Histone cluster 1, H2bj	Hist1h2bj	NM_178198	−3.58	0.001	Compaction of chromatin
Activating Transcriptional factor 4	Atf4	NM_009716	−3.29	0.004	Transcription activator, binds to CRE
Jun oncogene	Jun	NM_010591	−2.64	0.002	Transcription factor
Inhibitor of DNA binding 2	Id2	NM_010496	−2.3	0.032	Inhibitor of transcription factors
Nuclear receptor sub 4, 2	Nr4a2	NM_0113613	−1.80	0.007	Transcription factor
Nuclear receptor sub 4, 1	Nr4a1	NM_010444	−1.74	0.028	Transcription factor
Polymerase (RNA) II polypeptide K	Polr2k	NM_023127	1.013	0.042	RNA polymerase
Translation/cell survival
Poly(A)binding protein, cytoplas. 1	Pabpc1	NM_008774	−3.75	0.003	Poly(A) translation, initiation
Translation initiation factor 3, sub D	Eif3d	NM_018749	−1.92	0.009	Component of the eIF-3 complex
Programmed cell death 7	Pdcd7	NM_016688	−1.43	0.025	Promotes apoptosis
Protein Degradation
Myeloid leukemia factor 2	Mlf2	NM_145385	−3.03	0.0001	Protein degradation tagging activity
Ubiquitin-conjugated enzyme E2G 1	Ube2g1	NM_025985	−1.31	0.041	Attachment of ubiquitin to proteins
Unclassified
Abhydrolase domain containing 11	Abhd11	NM_145215	−2.38	0.001	Deleted Williams-Bernes syndrome

Relative mRNA levels in the hippocampus of APP_Sw,Ind mice compared to nontransgenic control mice after spatial training in the MWM. Relevant genes from microarray hybridizations are listed in each column, with log2-fold changes indicating relative decrease (<1) or increase (>1) of mRNA levels in APP_Sw,Ind mice compared with controls. Genes are grouped according to their biological pathway and relative gene expression changes. A gene could be assigned to more than one biological function term. Only genes with p < 0.05 are given.