Table 1.

Aβ-responsive genes in microglia for which EP4 signaling opposed the effect of Aβ by >1.5-fold

RefSeq//gene symbol//gene assignmentGeneFold changepFold changep
Genes upregulated by Aß42 oligomersAß42o-veh versus Con-VehAß42o + EP4 ag versus Aß42o-veh
NM_001033122 // Cd69 // CD69 antigenCd69127.223.2E-06−1.921.6E-01
NM_021274 // Cxcl10 // chemokine (C-X-C motif) ligand 10Cxcl1024.755.5E-04−1.753.6E-01
NM_138648 // Olr1 // oxidized low density lipoprotein (lectin-like) receptor 1Olr121.602.9E-09−1.894.0E-04
NM_054055 // Slc13a3 // solute carrier family 13Slc13a319.032.1E-09−1.717.3E-04
NR_027852 // Cd40 // CD40 antigenCd4016.962.1E-11−2.698.8E-08
NM_010260 // Gbp2 // guanylate binding protein 2Gbp216.912.3E-05−1.761.2E-01
NM_153564 // Gbp5 // guanylate binding protein 5Gbp516.531.2E-06−1.548.1E-02
NM_008204 // H2-M2 // histocompatibility 2, M region locus 2H2-M216.211.3E-10−1.733.8E-05
NM_009890 // Ch25h // cholesterol 25-hydroxylaseCh25h16.071.7E-08−2.527.2E-05
NM_030701 // Niacr1 // niacin receptor 1Niacr115.248.4E-11−1.781.6E-05
NM_172845 // Adamts4 // a disintegrin-like and metallopeptidaseAdamts411.243.3E-08−2.881.9E-05
NM_008331 // Ifit1 // interferon-induced protein with tetratricopeptide repeatsIfit110.352.9E-04−2.167.9E-02
NM_172648 // Ifi205 // interferon activated gene 205Ifi20510.233.2E-05−2.053.2E-02
NM_008599 // Cxcl9 // chemokine (C-X-C motif) ligand 9Cxcl96.896.0E-07−3.977.8E-06
NM_021384 // Rsad2 // radical S-adenosyl methionine domain containing 2Rsad26.842.7E-03−1.981.7E-01
NM_008332 // Ifit2 // interferon-induced protein with tetratricopeptide repeatsIfit26.463.5E-03−3.133.7E-02
NM_010846 // Mx1 // myxovirus (influenza virus) resistance 1Mx16.434.1E-04−3.216.8E-03
NR_029565 // Mir155 // microRNA 155Mir1556.195.3E-09−1.591.8E-04
NM_011909 // Usp18 // ubiquitin specific peptidase 18Usp185.894.0E-04−2.751.1E-02
NR_003508 // Mx2 // myxovirus (influenza virus) resistance 2Mx25.771.1E-05−3.301.8E-04
NM_029758 // Fam49a // family with sequence similarity 49, member AFam49a5.486.8E-07−1.702.5E-03
NM_001045481 // Ifi203 // interferon activated gene 203Ifi2035.469.2E-04−1.791.2E-01
NM_020557 // Cmpk2 // cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialCmpk25.402.8E-03−2.168.8E-02
NM_018734 // Gbp3 // guanylate binding protein 3Gbp35.261.7E-05−2.222.4E-03
NM_013652 // Ccl4 // chemokine (C-C motif) ligand 4Ccl45.002.7E-08−1.641.9E-04
NM_029084 // Slamf8 // SLAM family member 8Slamf84.966.1E-07−2.022.6E-04
NR_029806 // Mir221 // microRNA 221Mir2214.868.5E-08−1.851.0E-04
NM_001114665 // Fnbp1l // formin binding protein 1-likeFnbp1l4.552.8E-09−1.872.8E-06
NM_145545 // Gbp6 // guanylate binding protein 6Gbp64.253.1E-05−1.524.1E-02
NM_145066 // Gpr85 // G protein-coupled receptor 85Gpr854.196.0E-09−1.574.1E-05
NM_010657 // Hivep3 // human immunodeficiency virus type I enhancer binding prHivep34.142.8E-08−1.773.1E-05
NM_145968 // Tagap // T-cell activation Rho GTPase-activating proteinTagap4.051.5E-09−1.571.0E-05
NM_010104 // Edn1 // endothelin 1Edn13.911.6E-06−2.493.2E-05
NM_008607 // Mmp13 // matrix metallopeptidase 13Mmp133.876.2E-07−1.822.5E-04
NM_022331 // Herpud1 // homocysteine-inducible, endoplasmic reticulum stress-indHerpud13.681.6E-09−1.836.9E-07
NM_001033415 // Shisa3 // shisa homolog 3 (Xenopus laevis)Shisa33.632.9E-08−2.347.5E-07
NM_010755 // Maff // v-maf musculoaponeurotic fibrosarcoma oncogene familyMaff3.541.0E-06−1.648.9E-04
NM_001039530 // Parp14 // poly (ADP-ribose) polymerase family, member 14Parp143.382.4E-06−1.611.8E-03
NR_029807 // Mir222 // microRNA 222Mir2223.336.2E-07−1.741.9E-04
NM_008390 // Irf1 // interferon regulatory factor 1Irf13.323.8E-07−1.632.7E-04
NM_016850 // Irf7 // interferon regulatory factor 7Irf73.242.7E-03−1.561.4E-01
NM_001042611 // Cp // ceruloplasminCp3.215.0E-05−1.922.3E-03
NM_013654 // Ccl7 // chemokine (C-C motif) ligand 7Ccl73.091.1E-04−1.953.0E-03
NM_183177 // Zfp811 // zinc finger protein 811Zfp8113.052.1E-07−1.705.6E-05
NM_009425 // Tnfsf10 // tumor necrosis factor (ligand) superfamily, member 10Tnfsf102.982.0E-03−2.357.7E-03
NM_008330 // Ifi47 // interferon gamma inducible protein 47Ifi472.966.8E-04−2.086.8E-03
NM_181545 // Slfn8 // schlafen 8Slfn82.891.5E-05−1.731.4E-03
NM_028968 // Ifitm7 // interferon induced transmembrane protein 7Ifitm72.884.1E-07−1.745.1E-05
NM_001134457 // Fam55c // family with sequence similarity 55, member CFam55c2.872.9E-06−1.713.9E-04
NM_027835 // Ifih1 // interferon induced with helicase C domain 1Ifih12.872.5E-06−1.821.5E-04
NM_178607 // Rnf24 // ring finger protein 24Rnf242.842.5E-06−1.521.6E-03
ENSMUST00000131035 // Rnf213 // ring finger protein 213Rnf2132.821.9E-04−1.864.7E-03
NM_011331 // Ccl12 // chemokine (C-C motif) ligand 12Ccl122.801.3E-06−2.761.5E-06
NM_001037713 // Xaf1 // XIAP associated factor 1Xaf12.796.0E-05−1.881.5E-03
NM_011333 // Ccl2 // chemokine (C-C motif) ligand 2Ccl22.785.9E-05−1.762.8E-03
NM_023141 // Tor3a // torsin family 3, member ATor3a2.741.8E-05−1.769.6E-04
NM_019440 // Irgm2 // immunity-related GTPase family M member 2Irgm22.662.7E-05−2.101.9E-04
NM_009873 // Cdk6 // cyclin-dependent kinase 6Cdk62.615.7E-10−2.411.2E-09
NM_194336 // Mpa2l // macrophage activation 2 likeMpa2l2.603.2E-05−1.711.6E-03
NM_183201 // Slfn5 // schlafen 5Slfn52.564.4E-05−1.801.1E-03
NM_011579 // Tgtp1 // T-cell specific GTPase 1Tgtp12.561.3E-05−2.313.0E-05
NM_023386 // Rtp4 // receptor transporter protein 4Rtp42.522.1E-05−1.621.7E-03
NM_011579 // Tgtp1 // T-cell specific GTPase 1Tgtp12.501.1E-05−2.193.5E-05
NM_009277 // Trim21 // tripartite motif-containing 21Trim212.482.5E-06−1.691.4E-04
NM_183029 // Igf2bp2 // insulin-like growth factor 2 mRNA binding protein 2Igf2bp22.471.6E-07−1.621.9E-05
NM_008326 // Irgm1 // immunity-related GTPase family M member 1Irgm12.423.9E-04−2.237.3E-04
NM_021788 // Sap30 // sin3 associated polypeptideSap302.384.5E-06−1.751.1E-04
NM_011057 // Pdgfb // platelet derived growth factor, B polypeptidePdgfb2.361.2E-05−2.654.6E-06
NR_003507 // Oas1b // 2′-5′ oligoadenylate synthetase 1BOas1b2.355.7E-06−1.633.1E-04
NM_010828 // Cited2 // Cbp/p300-interacting transactivatorCited22.323.1E-06−1.756.3E-05
NM_025992 // Herc6 // hect domain and RLD 6Herc62.312.4E-05−1.648.5E-04
NM_008356 // Il13ra2 // interleukin 13 receptor, alpha 2Il13ra22.292.0E-07−1.724.9E-06
NM_145636 // Il27 // interleukin 27Il272.254.4E-08−1.863.6E-07
NM_010215 // Il4i1 // interleukin 4 induced 1Il4i12.213.0E-07−2.331.8E-07
NR_029728 // Mirlet7c-1 // microRNA let7c-1Mirlet7c-12.155.6E-06−2.031.0E-05
NM_013730 // Slamf1 // signaling lymphocytic activation molecule family member 1Slamf12.141.0E-06−1.594.3E-05
NM_027320 // Ifi35 // interferon-induced protein 35Ifi352.142.6E-04−1.576.5E-03
NM_172689 // Ddx58 // DEAD (Asp-Glu-Ala-Asp) box polypeptide 58Ddx582.081.1E-04−1.661.3E-03
NM_007829 // Daxx // Fas death domain-associated proteinDaxx2.071.3E-04−1.543.6E-03
NM_008360 // Il18 // interleukin 18Il182.067.1E-05−2.076.7E-05
NM_020583 // Isg20 // interferon-stimulated proteinIsg202.066.5E-04−1.531.3E-02
NM_016960 // Ccl20 // chemokine (C-C motif) ligand 20Ccl202.057.1E-04−1.589.5E-03
NR_029535 // Mir99a // microRNA 99aMir99a2.036.3E-06−1.871.6E-05
Genes downregulated by Aß42 oligomers
    NM_008676 // Nbr1 // neighbor of Brca1 gene 1Nbr1−2.027.0E-091.514.7E-07
    NM_001037957 // Dyrk1b // dual-specificity tyrosine-(Y)-phosphorylationDyrk1b−2.025.4E-081.901.2E-07
    NM_026875 // Ypel3 // yippee-like 3 (Drosophila)Ypel3−2.042.3E-081.624.8E-07
    NM_011505 // Stxbp4 // syntaxin binding protein 4Stxbp4−2.056.9E-041.598.5E-03
    NM_021356 // Gab1 // growth factor receptor bound protein 2-associated protein 1Gab1−2.065.5E-072.823.4E-08
    NM_010591 // Jun // Jun oncogeneJun−2.086.2E-061.822.8E-05
    NM_007797 // Ctla2b // cytotoxic T lymphocyte-associated protein 2 betaCtla2b−2.127.1E-072.165.9E-07
    NM_010847 // Mxi1 // Max interacting protein 1Mxi1−2.132.0E-083.921.8E-10
    ENSMUST00000162022 // Glis3 // GLIS family zinc finger 3Glis3−2.232.0E-051.655.4E-04
    NM_028149 // Fbxl20 // F-box and leucine-rich repeat protein 20Fbxl20−2.253.8E-081.823.9E-07
    NM_175445 // Rassf2 // Ras association (RalGDS/AF-6) domain family member 2Rassf2−2.262.0E-092.469.1E-10
    NM_025979 // Mastl // microtubule associated serine/threonine kinase-likeMastl−2.275.6E-041.601.4E-02
    NM_172589 // Lhfpl2 // lipoma HMGIC fusion partner-like 2Lhfpl2−2.321.1E-061.801.7E-05
    NM_133667 // Pdk2 // pyruvate dehydrogenase kinase, isoenzyme 2Pdk2−2.352.3E-062.097.0E-06
    NM_011454 // Serpinb6b // serine (or cysteine) peptidase inhibitorSerpinb6b−2.526.5E-071.704.0E-05
    NM_134250 // Havcr2 // hepatitis A virus cellular receptor 2Havcr2−2.614.6E-071.609.6E-05
    NM_021897 // Trp53inp1 // transformation related protein 53 inducibleTrp53inp1−2.747.8E-101.961.9E-08
    NM_007635 // Ccng2 // cyclin G2Ccng2−2.832.0E-061.897.7E-05
    NM_001081278 // Tbc1d4 // TBC1 domain family, member 4Tbc1d4−3.015.2E-081.632.7E-05
    NM_007901 // S1pr1 // sphingosine-1-phosphate receptor 1S1pr1−3.022.4E-072.607.6E-07
    NM_011050 // Pdcd4 // programmed cell death 4Pdcd4−3.282.9E-061.601.8E-03
    NM_133212 // Tlr8 // toll-like receptor 8Tlr8−3.553.5E-081.887.5E-06
    NM_145933 // St6gal1 // beta galactoside alpha 2,6 sialyltransferase 1St6gal1−3.597.4E-112.009.7E-09
    NM_146073 // Zdhhc14 // zinc finger, DHHC domain containing 14Zdhhc14−3.717.1E-092.391.8E-07
    NM_010658 // Mafb // v-maf musculoaponeurotic fibrosarcoma oncogene familyMafb−3.997.1E-102.091.0E-07
    NM_011882 // Rnasel // ribonuclease LRnasel−4.291.0E-072.513.5E-06
    NM_175116 // Lpar6 // lysophosphatidic acid receptor 6Lpar6−5.301.6E-091.545.4E-05
    NM_009183 // St8sia4 // ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransfSt8sia4−5.531.9E-102.532.4E-08
    NM_009911 // Cxcr4 // chemokine (C-X-C motif) receptor 4Cxcr4−5.652.4E-121.742.0E-08
    NM_010427 // Hgf // hepatocyte growth factorHgf−5.661.1E-091.729.7E-06
    NM_001042591 // Arrdc3 // arrestin domain containing 3Arrdc3−6.741.2E-081.953.8E-05
    NM_007564 // Zfp36l1 // zinc finger protein 36, C3H type-like 1Zfp36l1−8.017.3E-081.642.3E-03
    NM_146042 // Rnf144b // ring finger protein 144BRnf144b−8.342.0E-111.701.1E-06