Table 3.

Comparison of allele and genotype frequencies of 23 OPRM1 SNPs among mild, moderate, and severe groups

SNPAllele/genotypeMild (n = 21)Moderate (n = 162)Severe (n = 149)p value
rs1799971A0.7380.6640.6580.5825
G0.2620.3360.342
AA0.5240.4260.3960.7326
AG0.4290.4750.523
GG0.0480.0990.081
rs3798676C0.9290.9350.9020.3081
T0.0710.0650.098
CC0.9050.8700.8180.0984
CT0.0480.1300.169
TT0.0480.0000.014
rs4870266A0.1670.1910.1780.8711
G0.8330.8090.822
AA0.0000.0250.0340.8247
AG0.3330.3330.289
GG0.6670.6420.678
rs527434A0.7380.8730.8520.0624
G0.2620.1270.148
AA0.6190.7530.7520.0109
AG0.2380.2410.201
GG0.1430.0060.047
rs610231C0.1190.0650.0440.1218
T0.8810.9350.956
CC0.0000.0120.0000.1613
CT0.2380.1050.087
TT0.7620.8830.913
rs9371773A0.0240.0830.0440.0693
G0.9760.9170.956
AA0.0000.0000.0070.0706
AG0.0480.1670.074
GG0.9520.8330.919
rs9384174C0.6670.5980.6020.6907
T0.3330.4020.398
CC0.4290.3230.3880.2290
CT0.4760.5510.429
TT0.0950.1270.184
rs9479757A0.1900.0710.0540.0053
G0.8100.9290.946
AA0.0480.0000.0070.0080
AG0.2860.1420.094
GG0.6670.8580.899
rs2075572C0.6430.7870.7890.0909
G0.3570.2130.211
CC0.4290.6230.6580.1575
CG0.4290.3270.262
GG0.1430.0490.081
rs3798683A0.3100.3420.3260.8667
G0.6900.6580.674
AA0.0480.1060.0870.921
AG0.5240.4720.477
GG0.4290.4220.436
rs632499A0.2620.1360.0970.0086
C0.7380.8640.903
AA0.0480.0250.0130.0492
AC0.4290.2220.168
CC0.5240.7530.819
rs9397685A0.7860.7990.7680.6444
G0.2140.2010.232
AA0.5710.6420.5640.3605
AG0.4290.3150.409
GG0.0000.0430.027
rs3798688G0.9290.9170.8860.3666
T0.0710.0830.114
GG0.9050.8520.7990.4501
GT0.0480.1300.174
TT0.0480.0190.027
rs9371776A0.0240.0490.0740.2636
G0.9760.9510.926
AA0.0000.0060.0000.3021
AG0.0480.0860.148
GG0.9520.9070.852
rs2010884A0.2860.3920.4030.3453
G0.7140.6080.597
AA0.0950.1420.2010.2318
AG0.3810.5000.403
GG0.5240.3580.396
rs13195018A0.8100.9200.9260.0365
C0.1900.0800.074
AA0.6670.8400.8590.0320
AC0.2860.1600.134
CC0.0480.0000.007
rs9397687C0.6900.5680.5570.2597
T0.3100.4320.443
CC0.4760.3150.3420.3288
CT0.4290.5060.430
TT0.0950.1790.228
rs518596C0.2860.2250.2080.5106
T0.7140.7750.792
CC0.0950.0490.0470.8155
CT0.3810.3520.322
TT0.5240.5990.631
rs73576470A0.9520.9260.9160.6874
G0.0480.0740.084
AA0.9050.8520.8460.5746
AG0.0950.1480.141
GG0.0000.0000.013
rs7763748C0.7140.7440.7650.7016
T0.2860.2560.235
CC0.5240.5620.5700.7116
CT0.3810.3640.389
TT0.0950.0740.040
rs6557337C0.5000.6420.6480.1671
T0.5000.3580.352
CC0.2860.4070.4160.3056
CT0.4290.4690.463
TT0.2860.1230.121
rs483481C0.6430.6360.6810.4826
T0.3570.3640.319
CC0.3810.3830.4560.7526
CT0.5240.5060.450
TT0.0950.1110.094
rs569284G0.0240.0680.0570.5031
T0.9760.9320.943
GG0.0000.0000.000
GT0.0480.1360.1140.4750
TT0.9520.8640.886
  • For each SNP, both allele and genotype frequencies were constructed into a 2 × 3 or a 3 × 3 contingency table, respectively. Association was assessed using the Pearson χ2 measure (chisq.test) using R version 3.00.2.