Percentage structure brain differences in CNV carriers relative to their controls
| Without ICV correction | With ICV correction | |||
|---|---|---|---|---|
| Deletion carriers | Duplication carriers | Deletion carriers | Duplication carriers | |
| ICV | +7.5% | −6.8% | — | — |
| Brain volume | +9.7% | −9.3% | +1.5% | −2.9% |
| Gray matter | +8.8% | −8.3% | +1.0% | −2.0% |
| White matter | +12.7% | −11.1% | +2.4% | −3.9% |
| Surface area | +7.1% | −6.6% | −1.0% | −1.4% |
| Thickness | +0.8% | −1.7% | +0.8% | −1.8% |
| Hippocampus | +5.4% | −6.5% | 0.0% | −4.0% |
| Amygdala | +3.4% | −6.0% | −2.6% | +0.6% |
| Cerebellum | +5.9% | −7.7% | +0.7% | −3.3% |
| Thalamus | +11.3% | −10.8% | +5.0% | −4.8% |
| Caudate | +2.9% | −6.5% | −0.1% | +2.2% |
| Putamen | +2.8% | −3.7% | −0.9% | +0.2% |
| Brainstem | +9.2% | −10.5% | +3.5% | −3.9% |
The two leftmost columns reflect percentage differences between CNV carriers and controls without normalization for ICV. Differences reaching significance (p < 0.05) are displayed in boldface type to help visualize general patterns. The two rightmost columns display the same data with differences normalized for ICV. Note that except for the thalamus and a few other values, the differences are minimal after normalization by ICV.