Table 2.

Ramp currents of WT and mutant Na_v1.7 channels at multiple depolarizing rates

Na_v1.7 ramp current	0.2 mV/ms		0.24 mV/ms		0.3 mV/ms		0.4 mV/ms		0.6 mV/ms		1.2 mV/ms
Na_v1.7 ramp current	% of I_peak	V_peak (mV)	% of I_peak	V_peak (mV)	% of I_peak	V_peak (mV)	% of I_peak	V_peak (mV)	% of I_peak	V_peak (mV)	% of I_peak	V_peak (mV)
WT (n = 7)	0.608 ± 0.15	−45.3 ± 2.3	0.843 ± 0.20	−44.8 ± 1.8	1.22 ± 0.28	−44.5 ± 1.5	1.94 ± 0.45	−44.0 ± 1.8	3.46 ± 0.83	−41.6 ± 1.8	9.20 ± 1.7	−38.5 ± 1.9
R1279P (n = 25)	1.61 ± 0.15^**	−40.4 ± 0.84^*	1.96 ± 0.20^**	−40.0 ± 1.1^*	2.53 ± 0.24^**	−39.6 ± 0.96^*	3.55 ± 0.37^*	−39.0 ± 0.93^*	5.82 ± 0.57	−37.5 ± 0.88^*	13.2 ± 1.0	−33.8 ± 1.1^*
Δ	2.65X^**	4.9 mV^*	2.33X^**	4.8 mV^*	2.07X^**	4.9 mV^*	1.83X^*	5.0 mV^*	1.68X	4.1 mV^*	1.43X	4.7 mV^*