Table 3.

Action potential characterization for WT and mutant Nav1.7 channels in small DRG neurons

Nav1.7Spontaneously firing neuronsEvoked firing neuronsInput resistance (GΩ)RMP (mV)Action potential amplitude (mV)Half-width (ms)Voltage threshold (mV)Current threshold (pA)Repetitively firing neurons
WT1 of 27, 3.7%n = 260.878 ± 0.083−53.2 ± 0.98122 ± 1.64.16 ± 0.19−22.6 ± 1.5208 ± 217 of 26, 27%
R1279P10 of 35, 29%*n = 250.763 ± 0.067−46.9 ± 0.96***119 ± 2.14.73 ± 0.26−23.3 ± 1.7121 ± 18**18 of 25, 72%**
  • *p < 0.05 versus WT channels;

  • **p < 0.01 versus WT channels;

  • ***p < 0.001 versus WT channels.