Table 1.

GT1b-associated proteinsa

GeneProteinReference sequencebGT1b/GM1 binding ratiop value
NapgGamma-soluble NSF attachment protein (γ-SNAP)NP_001100854.17.31.2 × 10−8
Hsd17b12Estradiol 17-β-dehydrogenase 12NP_114455.16.57.4 × 10−8
NclnNicalin precursorNP_001014104.15.41.4 × 10−6
Atad1Thorase: ATPase family AAA domain-containing protein 1NP_001030174.15.22.0 × 10−6
Gnai2Guanine nucleotide-binding protein G(i) subunit α-2NP_112297.14.23.3 × 10−5
Cct7T-complex protein 1 subunit ηNP_001100073.14.15.4 × 10−5
  • aCell surface-enriched detergent-solubilized proteins isolated from neonatal rat cerebellar granule neurons that bound to GT1b > GM1 as determined by iTRAQ quantitative mass spectrometry on quadruplicate biological replicates with statistical significance that exceeded the Bonferroni correction (p < 10−4).

  • bNCBI protein sequence identifier from the Rattus norvegicus protein database.