Table 1.

GABA_A receptor-mediated mIPSC characteristics in control and NSW mice

Group (n)	Amplitude (pA)	Rise_10–90% (ms)^{^a}	Decay τ₁ (ms)^{^a}	Decay τ₂ (ms)^{^a}	Decay τ_w (ms)	IEI (s)
WT control endogenous
0.5 μm TTX (5)	30.8 ± 1.6	1.2 ± 0.2	12.6 ± 0.8	51.6 ± 3.9	27.2 ± 1.5	1.4 ± 0.1
1.0 μm TTX (5)	27.3 ± 2.4	1.1 ± 0.2	10.2 ± 0.6	48.5 ± 5.8	25.2 ± 2.9	1.6 ± 0.1
WT NSW endogenous
0.5 μm TTX (5)	30.3 ± 1.9	1.0 ± 0.1	11.5 ± 1.3	49.2 ± 5.5	25.3 ± 1.1	1.1 ± 0.2
1.0 μm TTX (5)	32.7 ± 1.4	0.9 ± 0.1	13.9 ± 1.1	49.0 ± 2.3	26.4 ± 2.8	1.4 ± 0.1
WT control
+1 μm GABA (10)	33.7 ± 2.6	1.2 ± 0.3	12.4 ± 0.6	49.6 ± 3.3	26.0 ± 0.9	1.6 ± 0.3
+ GABA + 300 nm AP (5)	31.5 ± 0.8	1.4 ± 0.1	12.6 ± 1.8	80.4 ± 8.3^*	34.6 ± 1.4^*	1.7 ± 0.2
WT NSW
+ 1 μm GABA (10)	33.8 ± 2.0	1.2 ± 0.2	14.4 ± 1.4	43.3 ± 4.2	25.3 ± 1.9	1.3 ± 0.2
+ GABA + 300 nm AP (5)	40.5 ± 2.1^^,^*	1.6 ± 0.3	16.5 ± 2.0	102.1 ± 7.9^*	42.2 ± 3.1^*	1.6 ± 0.3
δKO control
+ 1 μm GABA (9)	33.7 ± 2.2	1.3 ± 0.1	12.2 ± 0.9	47.8 ± 4.0	26.0 ± 2.6	1.8 ± 0.1
+GABA + 300 nm AP (9)	34.8 ± 1.3	1.5 ± 0.2	15.3 ± 1.4	58.5 ± 5.1^***	29.5 ± 1.1^***	1.7 ± 0.3
δKO NSW
+ 1 μm GABA (6)	32.4 ± 2.3	1.1 ± 0.2	11.7 ± 1.8	45.8 ± 6.0	22.5 ± 2.5	1.8 ± 0.6
+ GABA + 300 nm AP (5)	34.9 ± 2.0^***	1.0 ± 0.1	10.1 ± 1.0	47.9 ± 7.5^***	23.6 ± 2.3^***	1.6 ± 0.4

mIPSCs were recorded in the presence of 0.5 μm TTX unless denoted otherwise. Groups denoted as + GABA + 300 nm AP were recorded during perfusion of 1 μm GABA and 300 nm AP. Recordings were from voltage-clamped (−65 mV) DGGCs in hippocampus slices.
↵***p < 0.05 versus WT NSW + 1 μm GABA alone;
↵***p < 0.05 versus WT control + GABA + 300 nm AP;
↵***p < 0.05 versus WT NSW + GABA + 300 nm AP; independent two-tailed t test. IEI, Interevent interval as a measure of frequency. Data values represent mean ± SEM.
↵^aRise time, decay τ₁, and decay τ₂ are represented as R_t_, τ₁, and τ₂ in Figure 7C. Rise_10–90% represents duration for downward shift 10–90% of the amplitude.