State-dependent actions of bupivacaine on macroscopic responses
| Experimental | Simulation | |||||
|---|---|---|---|---|---|---|
| Condition (n = 6) | Peak (pA) | TauD (s) | Iss/Ipk | Peak (pA) | TauD (s) | Iss/Ipk |
| Control | −1006 ± 231 | 1.0 ± 0.1 | 0.62 ± 0.06 | −3517 | 1.4 | 0.76 |
| Coapplication bupivacaine + Glu | −816 ± 192* | 0.4 ± 0.03* | 0.35 ± 0.07* | −3235 | 0.5 | 0.17 |
| Ambient bupivacaine + Glu application | −315 ± 80* | 2.0 ± 0.6 | 0.68 ± 0.05 | −520 | 1.2 | 0.77 |
Data are mean ± SEM for each dataset.
↵* p < 0.05, significant difference from control (Student's t test).