Summary of behavioral deficits in S-SCAM Tg mice
| Behavioral symptoms | Behavioral test | Modeling | Male Tg | Female Tg |
|---|---|---|---|---|
| Positive | Open field | Psychomotor agitation | ↑ (Locomotor hyperactivity) | Normal |
| Prepulse inhibition | Sensorimotor gating | ↓ (Deficits) | ↓ (Deficits) | |
| Negative | Sociability (three chamber) | Social interaction | Normal | ↓ (Deficits) |
| Nest building test | Social interaction | Normal | ↓ (Deficits) | |
| Elevated plus maze | Anxiety | ↑ (Increased) | Normal | |
| Sucrose consumption | Anhedonia | Normal | ↓ (Reduced) | |
| Spontaneous alteration (Y-maze) | Spatial working memory | ↓ (Deficits) | Normal | |
| Cognitive | Contextual and cued fear conditioning | Reference memory | Normal | Normal |
| Social novelty (three chamber) | Social memory/social recognition | ↓ (Deficits) | Normal |