Signaling pathways enrichment in primary RMG cells from BN-J, Harlan, and Lewis rat strains
| Pathways | Enriched in | adj. p-value | ||||
|---|---|---|---|---|---|---|
| BNJ | BNH | Lewis | BNJ | BNH | Lewis | |
| D-GLOCUSE-INS1-RXRA | ✓ | 4,0E-02 | 5,5E-02 | 6,5E-02 | ||
| Pentose phosphate pathway | ✓ | 5,0E-02 | 5,8E-02 | 6,3E-02 | ||
| Type II interferon signaling (IFNG) | ✓ | 9,3E-03 | 6,1E-02 | 1,4E-01 | ||
| Urea cycle and metabolism of amino groups | ✓ | ✓ | 1,5E-02 | 2,0E-02 | 7,2E-02 | |
| ATM | ✓ | ✓ | ✓ | 4,7E-05 | 4,9E-04 | 1,0E-04 |
| Adipogenesis | ✓ | ✓ | ✓ | 1,8E-03 | 6,8E-06 | 2,9E-06 |
| Alpha6-Beta4 integrin signaling pathway | ✓ | ✓ | ✓ | 2,5E-03 | 1,0E-02 | 3,2E-03 |
| Androgen receptor signaling pathway | ✓ | ✓ | ✓ | 8,0E-16 | 6,6E-16 | 2,5E-14 |
| Apoptosis | ✓ | ✓ | ✓ | 2,7E-09 | 1,0E-08 | 5,8E-09 |
| Apoptosis modulation by HSP70 | ✓ | ✓ | ✓ | 4,8E-04 | 4,3E-03 | 6,6E-05 |
| B cell receptor signaling pathway | ✓ | ✓ | ✓ | 1,3E-19 | 2,9E-19 | 1,5E-17 |
| Beta oxidation meta pathway | ✓ | ✓ | ✓ | 4,1E-03 | 6,2E-03 | 6,8E-04 |
| CDKN1A-EGF-CREB | ✓ | ✓ | ✓ | 1,0E-08 | 2,7E-09 | 7,8E-09 |
| Calcium regulation in the cardiac cell | ✓ | ✓ | ✓ | 1,6E-02 | 1,8E-03 | 7,5E-05 |
| Cardiovascular signaling | ✓ | ✓ | ✓ | 6,7E-03 | 3,4E-03 | 1,4E-03 |
| Cell cycle | ✓ | ✓ | ✓ | 3,8E-14 | 1,5E-14 | 6,6E-13 |
| Cholesterol biosynthesis | ✓ | ✓ | ✓ | 9,6E-04 | 1,3E-03 | 1,5E-03 |
| Cholesterol metabolism | ✓ | ✓ | ✓ | 9,3E-05 | 1,6E-04 | 1,1E-03 |
| Cytoplasmic ribosomal proteins | ✓ | ✓ | ✓ | 1,7E-26 | 2,6E-25 | 2,3E-24 |
| DNA replication | ✓ | ✓ | ✓ | 2,6E-07 | 2,1E-09 | 8,3E-08 |
| Delta-Notch signaling pathway | ✓ | ✓ | ✓ | 1,0E-09 | 1,4E-11 | 2,0E-09 |
| Diurnally regulated genes with circadian orthologs | ✓ | ✓ | ✓ | 8,1E-07 | 2,0E-06 | 5,2E-07 |
| EBV LMP1 signaling | ✓ | ✓ | ✓ | 4,5E-03 | 1,3E-03 | 1,7E-03 |
| EGFR1 signaling pathway | ✓ | ✓ | ✓ | 1,3E-20 | 3,7E-20 | 6,4E-20 |
| EPO receptor signaling | ✓ | ✓ | ✓ | 1,4E-02 | 5,7E-03 | 2,4E-02 |
| Electron transport chain | ✓ | ✓ | ✓ | 2,6E-25 | 3,3E-24 | 1,3E-24 |
| Endochondral ossification | ✓ | ✓ | ✓ | 8,8E-03 | 1,3E-03 | 2,0E-03 |
| ErbB signaling pathway | ✓ | ✓ | ✓ | 9,8E-03 | 2,6E-03 | 9,7E-03 |
| Eukaryotic transcription initiation | ✓ | ✓ | ✓ | 6,9E-10 | 1,7E-09 | 3,1E-09 |
| FAS pathway and stress induction of HSP regulation | ✓ | ✓ | ✓ | 1,4E-08 | 3,9E-07 | 6,7E-07 |
| Fatty acid beta oxidation | ✓ | ✓ | ✓ | 2,1E-03 | 3,3E-03 | 3,3E-04 |
| Fatty acid beta oxidation 1 | ✓ | ✓ | ✓ | 2,3E-02 | 3,2E-02 | 4,3E-03 |
| Fatty acid beta oxidation 3 | ✓ | ✓ | ✓ | 2,0E-02 | 2,4E-02 | 2,7E-02 |
| G-protein signaling pathways | ✓ | ✓ | ✓ | 9,4E-06 | 1,8E-08 | 4,7E-08 |
| G1 to S cell cycle control | ✓ | ✓ | ✓ | 5,7E-08 | 4,7E-09 | 6,8E-08 |
| G13 signaling pathway | ✓ | ✓ | ✓ | 2,2E-03 | 2,8E-04 | 8,5E-05 |
| Glycogen metabolism | ✓ | ✓ | ✓ | 2,0E-03 | 7,0E-04 | 9,5E-04 |
| Glycolysis and Gluconeogenesis | ✓ | ✓ | ✓ | 1,7E-02 | 1,1E-02 | 1,5E-02 |
| Heme biosynthesis | ✓ | ✓ | ✓ | 2,3E-02 | 2,8E-02 | 3,1E-02 |
| Homologous recombination | ✓ | ✓ | ✓ | 1,0E-02 | 1,3E-02 | 1,6E-02 |
| IL-1 signaling pathway | ✓ | ✓ | ✓ | 1,2E-03 | 1,6E-03 | 1,1E-02 |
| IL-2 signaling pathway | ✓ | ✓ | ✓ | 4,9E-09 | 2,9E-09 | 4,2E-08 |
| IL-3 signaling pathway | ✓ | ✓ | ✓ | 2,3E-13 | 2,4E-14 | 1,1E-13 |
| IL-4 signaling pathway | ✓ | ✓ | ✓ | 8,6E-11 | 2,6E-10 | 7,0E-10 |
| IL-5 signaling pathway | ✓ | ✓ | ✓ | 2,4E-10 | 8,2E-11 | 2,1E-09 |
| IL-6 signaling pathway | ✓ | ✓ | ✓ | 1,9E-15 | 1,2E-16 | 4,9E-16 |
| IL-7 signaling pathway | ✓ | ✓ | ✓ | 4,1E-08 | 9,5E-08 | 1,9E-07 |
| IL-9 signaling pathway | ✓ | ✓ | ✓ | 3,9E-04 | 5,9E-04 | 7,6E-04 |
| Id signaling pathway | ✓ | ✓ | ✓ | 2,6E-04 | 1,5E-04 | 6,5E-05 |
| Insulin signaling | ✓ | ✓ | ✓ | 1,2E-15 | 6,0E-16 | 4,9E-19 |
| Integrin-mediated cell adhesion | ✓ | ✓ | ✓ | 3,2E-06 | 3,4E-06 | 6,8E-07 |
| Keap1-Nrf2 | ✓ | ✓ | ✓ | 3,4E-02 | 4,3E-02 | 1,0E-02 |
| Kit receptor signaling pathway | ✓ | ✓ | ✓ | 3,6E-08 | 1,9E-08 | 2,3E-07 |
| MAPK cascade | ✓ | ✓ | ✓ | 2,1E-04 | 5,3E-05 | 4,2E-07 |
| MAPK signaling pathway | ✓ | ✓ | ✓ | 9,2E-16 | 2,2E-15 | 3,3E-15 |
| Mitochondrial gene expression | ✓ | ✓ | ✓ | 3,1E-03 | 4,4E-03 | 5,5E-03 |
| Mitochondrial LC-fatty acid beta-oxidation | ✓ | ✓ | ✓ | 1,9E-03 | 2,6E-03 | 3,2E-03 |
| Myometrial relaxation and contraction pathways | ✓ | ✓ | ✓ | 1,2E-07 | 3,3E-08 | 2,0E-09 |
| NR3C1-PKL1 | ✓ | ✓ | ✓ | 4,2E-06 | 9,9E-06 | 1,7E-05 |
| Non-homologous end joining | ✓ | ✓ | ✓ | 3,6E-02 | 4,3E-02 | 4,7E-02 |
| Notch signaling pathway | ✓ | ✓ | ✓ | 1,4E-03 | 2,3E-04 | 3,4E-03 |
| Nucleotide metabolism | ✓ | ✓ | ✓ | 8,9E-05 | 1,3E-04 | 1,5E-04 |
| One carbon metabolism | ✓ | ✓ | ✓ | 2,4E-02 | 3,4E-02 | 4,1E-02 |
| Oxidative stress | ✓ | ✓ | ✓ | 1,5E-03 | 2,1E-03 | 6,6E-05 |
| Oxidative phosphorylation | ✓ | ✓ | ✓ | 2,2E-17 | 1,1E-16 | 3,3E-16 |
| PI3K_AKT_NFKB pathway | ✓ | ✓ | ✓ | 5,4E-06 | 1,2E-05 | 3,4E-06 |
| PKC-SCP2 | ✓ | ✓ | ✓ | 3,2E-04 | 2,5E-04 | 4,1E-04 |
| Proteasome degradation | ✓ | ✓ | ✓ | 1,5E-11 | 4,8E-11 | 1,3E-10 |
| Regulation of actin cytoskeleton | ✓ | ✓ | ✓ | 2,0E-06 | 2,0E-07 | 2,4E-07 |
| Renin–angiotensin system | ✓ | ✓ | ✓ | 6,0E-04 | 1,1E-04 | 4,8E-05 |
| Selenium metabolism selenoproteins | ✓ | ✓ | ✓ | 2,3E-03 | 3,3E-03 | 4,0E-03 |
| Senescence and autophagy | ✓ | ✓ | ✓ | 6,5E-08 | 2,9E-08 | 6,6E-08 |
| Signal transduction of S1P | ✓ | ✓ | ✓ | 7,1E-03 | 9,9E-03 | 3,2E-03 |
| Signaling of hepatocyte growth factor receptor | ✓ | ✓ | ✓ | 1,0E-08 | 2,1E-08 | 4,2E-08 |
| T cell receptor signaling pathway | ✓ | ✓ | ✓ | 1,3E-09 | 7,3E-09 | 2,2E-07 |
| TCA cycle | ✓ | ✓ | ✓ | 2,9E-05 | 5,0E-05 | 6,6E-05 |
| TGF beta signaling pathway | ✓ | ✓ | ✓ | 9,3E-05 | 2,7E-06 | 4,6E-06 |
| TGF-beta receptor signaling pathway | ✓ | ✓ | ✓ | 1,1E-19 | 2,2E-21 | 1,6E-19 |
| TNF-alpha NF-kB signaling pathway | ✓ | ✓ | ✓ | 6,4E-32 | 1,1E-32 | 2,2E-30 |
| TNF-alpha and mucus production in lung epythelium | ✓ | ✓ | ✓ | 3,2E-06 | 5,7E-06 | 7,7E-06 |
| The effect of glucocorticoids on target gene expression | ✓ | ✓ | ✓ | 2,7E-03 | 3,6E-03 | 4,3E-03 |
| Toll-like receptor signaling pathway | ✓ | ✓ | ✓ | 3,1E-08 | 1,0E-07 | 5,3E-09 |
| Translation factors | ✓ | ✓ | ✓ | 9,3E-11 | 2,5E-10 | 5,7E-10 |
| VEGF-receptor signal transduction | ✓ | ✓ | ✓ | 9,3E-04 | 5,4E-03 | 3,4E-04 |
| Wnt signaling pathway net path | ✓ | ✓ | ✓ | 3,6E-08 | 4,1E-08 | 5,7E-10 |
| Wnt signaling pathway and pluripotency | ✓ | ✓ | ✓ | 2,2E-03 | 1,3E-03 | 1,2E-05 |
| Estrogen signaling | ✓ | ✓ | ✓ | 4,5E-13 | 1,2E-13 | 4,0E-13 |
| Genetic alternations of lung cancer | ✓ | ✓ | ✓ | 3,5E-05 | 5,6E-05 | 7,5E-05 |
| mRNA processing | ✓ | ✓ | ✓ | 0,0E + 00 | 2,4E-25 | 0,0E + 00 |
| p38 MAPK signaling pathway (BioCarta) | ✓ | ✓ | ✓ | 2,5E-07 | 5,9E-06 | 4,3E-08 |
| p53 pathway | ✓ | ✓ | ✓ | 7,1E-07 | 4,3E-05 | 2,9E-06 |
| p53 signal pathway | ✓ | ✓ | ✓ | 2,1E-04 | 3,3E-04 | 4,6E-04 |
| Alanine and aspartate metabolism | ✓ | 5,6E-01 | 5,9E-01 | 4,1E-02 | ||
| Fatty acid biosynthesis | ✓ | 7,2E-02 | 8,9E-02 | 9,9E-03 | ||
| NLR proteins | ✓ | 1,3E-01 | 1,4E-01 | 2,9E-02 | ||
| Wnt signaling pathway | ✓ | 2,1E-01 | 1,2E-01 | 3,2E-02 | ||
List of enriched Wikipathway signaling pathways from genes expressed in BNJ, BNH, and Lewis rat RMG cells and their corresponding significance (adjusted P-values).