Reported half-maximal inhibitory concentration (IC50) of each tested PKC inhibitor for each mammalian PKC isoforma
| Isoform/inhibitor | Gö 6983 (nm) | NPC | CID (μm) | BIS (nm) | Sotrastaurin (nm) |
|---|---|---|---|---|---|
| α | 7 | + | >>10 | 8 | 1 |
| β | 7 | + | >10 | 20 | 0.6 |
| γ | 6 | + | - | 2–6 | - |
| δ | 10 | + | >>7 | 0.2 | 2 |
| ε | - | + | - | 0.1 | 3 |
| η | - | + | - | - | 2 |
| μ (PKD) | 20 | - | 0.2 | 2 | - |
| θ | - | - | - | 20 | 0.2 |
| ι/λ | - | - | - | - | - |
| ζ | 60 | + | - | 6 | - |
↵aClassical (α, β, and γ), novel (δ, ζ, η, μ, θ), and atypical PKC isoforms (ι/λ, ζ) are shown. All IC50 values were obtained from published studies (see Materials and Methods). For NPC, no published IC50 values are available, but known inhibitory activity is denoted with a plus sign (+). Hyphen (-) indicates no known activity at the particular PKC isoform.