Loss of progranulin does not shorten lifespan in TDP-43 animals
| Strain | Trial | Mean lifespan ± SEM | Events/obs | Percentage difference from N2 | p value summary vs N2 | p value summary vs pgrn-1 |
|---|---|---|---|---|---|---|
| N2 | 1 | 13.8 ± 0.8 | 77/90 | — | — | — |
| pgrn-1(-) | 14.4 ± 0.7 | 83/90 | 4.3 | ns | — | |
| N2;TDP-43 | 11.3 ± 0.7 | 79/90 | −18.1 | ns | ns | |
| pgrn-1(-);TDP-43 | 15.7 ± 0.7 | 77/90 | 13.8 | ns | ns | |
| N2 | 2 | 16.2 ± 0.5 | 71/90 | — | — | — |
| pgrn-1(tm985) | 14.4 ± 0.5 | 67/90 | −11.2 | * | — | |
| N2;TDP-43 | 14.9 ± 0.6 | 80/90 | −7.8 | ns | ns | |
| pgrn-1(-);TDP-43 | 16.1 ± 0.7 | 56/90 | −0.9 | ns | * | |
| N2 | 3 | 14.7 ± 0.7 | 54/80 | — | — | — |
| pgrn-1(-) | 14.2 ± 0.7 | 50/80 | −3.4 | ns | — | |
| N2;TDP-43 | 11.6 ± 0.6 | 60/80 | −21.0 | ns | ns | |
| pgrn-1(-);TDP-43 | 13.2 ± 0.8 | 40/80 | −10.2 | ns | ns |
Three independent lifespan trials were performed comparing wild-type and pgrn-1(-) strains with and without TDP-43. Average lifespans of strains were compared using the Mantel–Cox statistical test (ns, not significant;
↵*p < 0.01).