Table 1.

Aβ40 and Aβ42 in blood plasma and cerebral cortex at 16 months

	Females		Males
	Control	ADINKO	Control	ADINKO
Aβ40
Plasma concentration (pg/ml)	769 ± 74	953 ± 37 ^**	808 ± 42	798 ± 84
Total amount in plasma (ng) ^{^a}	2.1 ± 0.3	3.0 ± 0.2 ^*	2.5 ± 0.1	3.0 ± 0.4
Soluble amount in cortex (ng) ^{^b}	120 ± 27	51 ± 8 ^*	60 ± 10	28 ± 4 ^*
Plasma/cortex ratio (%)	3.0 ± 1.3	7.1 ± 0.9 ^**	6.3 ± 1.8	12.2 ± 2.2 ^**
Aβ42
Plasma concentration (pg/ml)	389 ± 45	541 ± 23 ^*	488 ± 39	485 ± 40
Total amount in plasma (ng) ^{^a}	1.1 ± 0.1	1.7 ± 0.1 ^**	1.5 ± 0.1	1.8 ± 0.2
Soluble amount in cortex (ng) ^{^b}	550 ± 47	382 ± 33 ^*	443 ± 54	267 ± 32 ^*
Plasma/cortex ratio (%)	0.21 ± 0.04	0.48 ± 0.04 ^**	0.44 ± 0.11	0.77 ± 0.11 ^**

↵ ^a Aβ plasma pool was determined from concentration and plasma volume (80 μl g⁻¹ of body weight; (Gunji et al., 2002).
↵ ^b Amount of soluble Aβ in cortex was calculated from concentration (Fig. 3 B) and cortex weight.
↵*p < 0.05 and
↵**p < 0.01, ADINKO versus control.
Mean ± SEM, n = 7–12, Mann–Whitney U test.