Table 3.

Brain coordinates corresponding to cerebral blood flow activations/deactivations in Figures 4, 5, 6, and 7

RegionZ score(x, y, z)
Figure 4: MRI B: Main effect pain
    Mindfulness meditation group
        ActivationRight cerebellum5.604, −74, −36
Left cerebellum3.50−12, −64, −26
Midcingulate cortex3.606, −4, 38
Right anterior insula3.2034, 20, 2
Right SII3.5152, 4, 2
Right thalamus3.5512, −10, 2
SMA2.78−4, −4, 68
SI3.35−8, −44, 68
        DeactivationS. frontal gyrus3.056, 56, 32
PCC/precuneous3.446, −48, 30
mPFC4.446, 52, −8
    Placebo group
        ActivationRight cerebellum4.4018, −42, −22
Left cerebellum3.05−24, −66, −30
Midcingulate cortex3.606, −14, 32
Right anterior insula3.1232, 18, 2
Left anterior insula3.92−34, 12, 2
Right posterior insula3.3038, −10, 2
Left posterior insula3.18−36, −20, 2
Left SII4.85−50, −4, 2
Right SII4.0050, 4, 2
Left thalamus3.48−12, −20, 2
Right thalamus3.588, −6, 2
SMA3.56−4, −10, 68
SI3.52−12, −44, 68
        DeactivationPCC/precuneous4.006, −52, 30
    Sham-mindfulness meditation group
        ActivationRight cerebellum4.514, 50, −10
Left cerebellum4.81−4, −48, −12
Midcingulate cortex6.16−4, −4, 38
Frontal operculum3.5138, 22, 2
Right anterior insula7.0040, 10, 2
Left anterior insula6.17−38, 4, 2
Left SII3.95−56, −2, 6
Right SII4.8754, 4, 6
SMA4.02−6, −8, 68
SI3.82−10, −46, 68
        DeactivationS. frontal gyrus3.246, 52, 30
PCC/precuneous4.376, −54, 36
mPFC3.166, 58, −10
    Control group
        ActivationRight cerebellum5.8612, −60, −22
Left cerebellum4.17−20, −66, −28
Midcingulate cortex4.126, −6, 44
Frontal operculum4.4534, 26, 6
Right anterior insula6.9634, 6, 6
Left anterior insula5.10−34, 8, 6
Left SII5.32−54, 2, 6
Right SII5.3348, 2, 6
SMA6.64−6, −6, 68
SI4.14−12, −42, 68
        DeactivationS. frontal gyrus4.276, 54, 32
PCC/precuneous4.100, −54, 24
mPFC4.116, 58, −2
    Control > mindfulness meditation
        ActivationDLPFC4.10−34, 14, 58
    Placebo > mindfulness meditation
        ActivationDLPFC3.82−26, 28, 58
    Sham-mindfulness meditation > mindfulness meditation
        ActivationDLPFC4.65−30, 18, 58
Figure 5: Mri B: Main effect of mindfulness meditation, placebo and comparisons
    Main effect of mindfulness meditation
        ActivationACC5.102, 30, 20
Right putamen3.1022, 8, −8
Left putamen3.05−20, 8 −8
Right anterior insula3.2538, 18, −8
Left anterior insula3.09−38, 6, −8
Left inferior frontal gyrus3.19−44, 24, 10
Right inferior frontal gyrus4.3944, 22, 10
Left parietal operculum/SII2.71−56, −10, 14
Right parietal operculum/SII3.1856, −8, 14
Right S13.1964, 0, 16
Left SI3.16−64, 0, 16
Right SI3.8350, −16, 40
        DeactivationRight cerebellum6.8530, −80, −32
Right superior frontal gyrus4.176, 54, 28
Left superior frontal gyrus4.20−6, 56, 30
PCC4.966, −44, 28
mPFC4.396, 60, −10
Left DLPFC5.81−34, 32, 40
Right DLPFC8.6624, 36, 40
    Main effect of placebo
        ActivationLeft anterior insula2.85−34, 8, −14
        DeactivationACC6.256, −4, 46
PCC5.448, −34, 40
    Mindfulness meditation > placebo
        ActivationACC3.236, 26, 32
PCC2.846, −32, 38
Right putamen4.3924, 2, 8
Left putamen3.10−22, 4, 8
Right inferior frontal gyrus3.0846, 26, 8
Right anterior insula2.4436, 20, −2
Right parietal operculum/SII3.0948, −10, 14
Left parietal operculum/SII3.14−54, −6, 14
Right SI3.6752, −8, 40
Left SI3.16−60, −12, 40
    Placebo > mindfulness meditation
        ActivationmPFC3.976, 56, −18
PCC3.766, −48, 26
Right cerebellum3.866, −62, −18
Left cerebellum4.14−6, −62, −18
Left thalamus5.75−4, −20, 6
Right thalamus4.638, −22, 6
PAG2.960, −28, −8
Left DLPFC3.82−36, 30, 40
Right DLPFC4.5134, 38, 40
Conjunction: Mindfulness meditation + placebo
    ActivationLeft anterior insula2.84−36, 8, −12
Figure 6: MRI B: Main effect of mindfulness meditation, sham-mindfulness meditation and comparisons
    Main effect of sham-mindfulness meditation
        ActivationLeft putamen/globus pallidus4.31−20, 8, −6
Right putamen/globus pallidus2.9020, 6, −6
Right SI5.5652, −8, 36
        DeactivationACC4.006, 38, −2
Superior frontal gyrus4.886, 50, 40
PCC/precuneous8.826, −56, 28
Right cerebellum6.616, −62, −28
Left cerebellum5.91−6, −64, −26
Left DLPFC4.07−30, 28, 36
Mindfulness meditation > sham-mindfulness meditation
Activation
Precuneous2.736, −64, 26
Right Putamen3.0126, −2, −6
Sham-mindfulness meditation > mindfulness meditation
    ActivationRight cerebellum3.286, −66, −20
Left cerebellum3.01−6, −54, −18
PAG4.680, −26, −6
Right thalamus2.738, −22, 2
Left thalamus4.44−8, −22, 2
Left DLPFC2.67−36, 30, 36
Right DLPFC4.6728, 42, 36
    Conjunction: Mindfulness meditation + sham-mindfulness meditation
        ActivationRight putamen2.8224, 4, −6
Left putamen3.12−24, 4, −6
Right SI3.0448, −10, 36
        DeactivationmPFC3.266, 58, −16
Right superior frontal gyrus2.796, 52, 32
Left superior frontal gyrus2.44−6, 56, 32
PCC/precuneous8.006, −50, 30
Right cerebellum7.196, −64, −28
Left cerebellum4.91−6, −64, −28
Left DLPFC3.71−24, 32, 36
Right DLPFC2.5424, 32, 36
Figure 7: MRI B: Neural correlates of group-manipulation induced pain changes during “heat” series
A: Neural correlates of mindfulness-based pain relief
    Mean effect of mindfulness meditation
        ActivationRight putamen3.2924, 2, 2
Left putamen3.54−24, 2, 2
Left inferior frontal gyrus4.03−48, 36, 2
Right inferior frontal gryus2.9648, 36, 2
Right SI3.0746, −16, 38
        DeactivationmPFC4.370, 60, 16
PCC4.56−4, −42, 38
    Neural correlates of mindfulness-based pain intensity reductions
        ActivationsgACC5.61−6, 40, −12
Right OFC7.6528, 44, −12
Left OFC4.45−32, 42, −12
Right anterior insula4.0530, 18, 10
Right putamen9.1226, 8, 10
Right inferior frontal gyrus2.9540, 20, 10
    Neural correlates of mindfulness-based pain unpleasantness reductions
        ActivationLeft inferior frontal gyrus2.77−48, 20, 4
Left frontal operculum2.68−52, 0, 14
    Neural correlates of mindfulness-based pain intensity increases
        ActivationLeft inferior parietal lobe5.66−42, −50, 38
B: Neural correlates of placebo-induced analgesia
    Mean effect of placebo
        ActivationACC3.8710, 44, 22
Right DLPFC2.5016, 44, 38
Left DLPFC3.96−40, 22, 38
        DeactivationRight posterior insula2.9238, −16, 8
Left posterior insula6.34−38, −20, 8
Left frontal operculum3.32−34, 14, 8
Left SII/parietal operculum2.67−40, −14, 14
Right SII/parietal operculum2.7336, −18, 14
Left inferior frontal gyrus2.86−52, 14, 14
    Neural correlates of placebo-induced pain intensity reductions
        DeactivationLeft SII/parietal operculum3.19−50, −16, 10
Left SII/parietal operculum3.91−64, −16, 10
C: The mean effect of sham mindfulness meditation
    ActivationSMA3.778, 2, 54
Left putamen4.15−18, 6, −4
Left thalamus3.60−2, −14, −4
Right SI4.4352, −12, 42
    DeactivationACC2.938, 48, 12
  • ACC, Anterior cingulate cortex; SII, secondary somatosensory cortex; SI, primary somatosensory cortex; PCC, posterior cingulate cortex; mPFC, medial prefrontal cortex; DLPFC, dorsolateral prefrontal cortex; PAG, periaqueductal gray matter; sgACC, subgenual ACC; SMA, supplemental motor area; OFC, orbitofrontal cortex.