Table 3.

Effects of intra-VTA CRF-R antagonism during stress on cocaine self-administration FR performance rate, progressive ratio breakpoint (PRBP), and infusions during a 24 h “binge”

Group	Drug	Region	FR rate	PRBP	Binge
Nonstressed	aCSF	aVTA	0.59 ± 0.09	7.49 ± 1.13	179.99 ± 44.64
Nonstressed	aCSF	pVTA	0.64 ± 0.08	9.71 ± 0.56	216.00 ± 32.80
Nonstressed	CP	aVTA	0.85 ± 0.21	10.67 ± 2.03	183.33 ± 85.47
Nonstressed	CP	pVTA	0.99 ± 0.22	10.79 ± 1.36	252.00 ± 51.80
Nonstressed	A2B	aVTA	0.55 ± 0.23	9.71 ± 0.83	233.00 ± 67.42
Nonstressed	A2B	pVTA	0.90 ± 0.13	11.67 ± 1.07	228.50 ± 63.29
Stressed	aCSF	aVTA	0.76 ± 0.22	10.42 ± 1.32	342.50 ± 41.19^**
Stressed	aCSF	pVTA	0.82 ± 0.05	10.87 ± 0.85	423.00 ± 48.69^**
Stressed	CP	aVTA	1.19 ± 0.15	10.67 ± 0.68	370.40 ± 64.36
Stressed	CP	pVTA	0.79 ± 0.12	8.83 ± 1.06	111.40 ± 26.72^###
Stressed	A2B	aVTA	0.73 ± 0.08	8.38 ± 1.21	94.50 ± 30.68^###
Stressed	A2B	pVTA	0.88 ± 0.06	11.92 ± 0.88	314.67 ± 41.03

Data are represented as mean ± SEM.
↵**p < 0.01 versus nonstressed aCSF;
↵###p < 0.001 versus stressed aCSF within the same subregion.