Synergistic effect of β-catenin overexpression, Notch1 deletion, and Atoh1 overexpression on mitotic HCs generation
| Control (n = 4) | Atoh1-OE (n = 3) | β-cat-OE Atoh1-OE (n = 3) | β-cat-OE Notch1-KO Atoh1-OE (n = 3) | |
|---|---|---|---|---|
| EdU+Myo7a+ HCs/cochlea | ||||
| Sensory region | 0 | 0.67 ± 0.67 | 3.67 ± 1.67 | 122.67 ± 9.87 |
| GER | 0 | 1.67 ± 1.20 | 70.67 ± 4.67 | 296.67 ± 14.95 |
| Myo7a+HCs/100 μm GER | ||||
| Proliferative HCs | 13.17 ± 1.17 | |||
| Nonproliferative HCs | 78.17 ± 5.83 |