Lesion status | Glutamate | GABA |
---|---|---|
Sham | — | — |
Ipsilateral to lesion | ↓ | ↑ |
Contralateral to lesion | — | ↑ |
↵aChanges in basal amino acid efflux (pg of glutamate or GABA/μl of dialysate) as a result of chronic l-DOPA were dependent on the presence of a 6-hydroxydopamine lesion. ↑, increase in neurotransmitter concentration versus treatment-naive subjects; ↓, decrease in neurotransmitter concentration versus treatment-naive subjects.