Table 5.

Neural signatures of double-update learning (RPEDU) for both healthy control subjects and alcohol-dependent patients taken together at p < 0.05 FWE whole brain corrected

Double-update signals
MNI coordinatesCluster sizetPeak p value (FWE corrected)
Middle orbital gyrus−2, 56, −4268111.20<0.001
Rectal gyrus−6, 44, −1010.52<0.001
Inferior frontal gyrus−34, 36, −1010.20<0.001
Inferior frontal gyrus34, 36, −12866.77<0.001
Superior frontal gyrus−12, 48, 361906.65<0.001
Superior frontal gyrus−18, 38, 505.790.002
Middle frontal gyrus−24, 32, 505.760.002
Insula−38, −2, 14375.880.001
Ventral striatum−6, 8, −103867.43<0.001
Ventral striatum10, 12, −87.01<0.001
Anterior cingulate cortex2, 20, 06.66<0.001
Caudate20, 18, 26525.590.005
Hippocampus−30, −12, −181887.61<0.001
Hippocampus32, −28, −105.880.001
Fusiform gyrus−32, −36, −145.50.007
Hippocampus38, −24, −14526.44<0.001
Fusiform area42, −18, −185.880.001
Posterior cingulate gyrus−2, −42, 3212019.05<0.001
Precuneus−6, −54, 188.7<0.001
Posterior cingulate gyrus−4, −52, 268.14<0.001
Middle temporal gyrus−50, −70, 221806.23<0.001
Angular gyrus−46, −72, 325.960.001
Middle temporal gyrus−44, −60, 225.920.001
Middle temporal gyrus58, −8, −22296.25<0.001
Middle temporal gyrus−60, −10, −20526.120.001
Superior temporal gyrus68, −22, 14175.50.016
Superior temporal gyrus60, −24, 165.190.025
Temporal pole56, 2, 6225.790.002
Operculum44, −20, 20405.670.004
Precentral gyrus42, −16, 626.14<0.001
Postcentral gyrus40, −26, 58695.070.038