KEGG pathway analysis of up and down-regulated genes in MBD1-KO cells
| Adjusted p-value | Genes | |
|---|---|---|
| Upregulated genes | ||
| Metabolic pathways | 4.86E-09 | Tk1, Gmppa, Naglu, Mvd, Dct, Mri1, Hexb, Hsd11b1, Polr1e, Pi4k2b, Alg6, Cbr3, Ndufs4, Cd38, Khk, Scly, Polr2d |
| Pyrimidine metabolism | 0.0051 | Tk1, Polr2d, Polr1e, Ctss |
| Lysosome | 0.0059 | Hexb, Naglu |
| Alzheimer's disease | 0.0107 | Grin2c, Ndufb11, Ndufs4 |
| Huntington's disease | 0.0109 | Ndufb11, Ndufs4, Polr2d |
| Downregulated genes | ||
| MAPK signaling pathway | 0.0018 | Fos, Map3k8, Mapk11, Cacnb1, Rasrgp1, Nfkb2 |
| Focal adhesion | 0.0064 | Col1a2, Col6a3, Pdgfc, Col4a5 |
| Pathways in cancer | 0.0063 | Ctnna3, Fos, Col4a5, Nfkb2, Pias |