Table 3.

Multiple regression results^{^a}

	Water content				Proton density
	Adjusted R²	R² change	F	p	Adjusted R²	R² change	F	p
Gray matter decreases in patients compared with control
PCC R
BP_ND	0.35	0.06	3.2	0.082	0.53	0.06	3.2	0.082
T1/PD		0.20^{^b}	12.7^{^b}	0.001^{^b}		0.40^{^b}	35.5^{^b}	<0.001^{^b}
Group		0.12^{^b}	9.2^{^b}	0.004^{^b}		0.08^{^b}	8.3^{^b}	0.006^{^b}
Group × BP_ND		0.04	2.8	0.102		0.04	3.9	0.055
Group × T1/PD		0.00	0.1	0.730		0.00	0.0	0.961
Fusiform R
BP_ND		0.01	0.4	0.509	0.33	0.01	0.4	0.509
T1/PD		0.01	0.6	0.452		0.04	2.1	0.158
Group		0.31^{^b}	21.2^{^b}	<0.001^{^b}		0.30	21.2^{^b}	<0.001^{^b}
Group × BP_ND		0.02	1.4	0.249		0.02	1.3	0.253
Group × T1/PD		0.05	3.8	0.058		0.03	2.2	0.141
Insula L
BP_ND	0.31	0.11^{^b}	5.9^{^b}	0.018^{^b}	0.38	0.11^{^b}	5.9^{^b}	0.018^{^b}
T1/PD		0.15^{^b}	9.8^{^b}	0.003^{^b}		0.23^{^b}	16.6^{^b}	<0.001^{^b}
Group		0.11^{^b}	8.1^{^b}	0.007^{^b}		0.08^{^b}	6.1^{^b}	0.017^{^b}
Group × BP_ND		0.01	0.4	0.515		0.00	0.3	0.585
Group × T1/PD		0.00	0.1	0.820		0.02	2.0	0.168
Insula R
BP_ND	0.34	0.06	3.4	0.072	0.42	0.06	3.4	0.072
T1/PD		0.23^{^b}	15.3^{^b}	<0.001^{^b}		0.29^{^b}	21.8^{^b}	<0.001^{^b}
Group		0.11^{^b}	8.9^{^b}	0.005^{^b}		0.10^{^b}	8.3^{^b}	0.006^{^b}
Group × BP_ND		0.00	0.1	0.702		0.01	1.1	0.298
Group × T1/PD		0.00	0.1	0.786		0.01	0.8	0.377
MPFC R
BP_ND	0.68	0.12^{^b}	6.6^{^b}	0.013^{^b}	0.77	0.12^{^b}	6.6^{^b}	0.013^{^b}
T1/PD		0.55^{^b}	79.3^{^b}	<0.001^{^b}		0.65^{^b}	131.1^{^b}	<0.001^{^b}
Group		0.04^{^b}	6.5^{^b}	0.014^{^b}		0.03^{^b}	6.2^{^b}	0.016^{^b}
Group × BP_ND		0.01	1.0	0.326		0.00	0.3	0.578
Group × T1/PD		0.00	0.3	0.594		0.00	0.9	0.347
ACC L
BP_ND	0.29	0.00	0.0	0.930	0.32	0.00	0.0	0.930
T1/PD		0.13^{^b}	6.9^{^b}	0.012^{^b}		0.20^{^b}	11.8^{^b}	0.001^{^b}
Group		0.21^{^b}	14.6^{^b}	<0.001^{^b}		0.16^{^b}	11.9^{^b}	0.001^{^b}
Group × BP_ND		0.02	1.6	0.206		0.03	1.9	0.180
Group × T1/PD		0.00	0.0	0.861		0.00	0.2	0.695
Precuneus R
BP_ND	0.62	0.02	0.8	0.376	0.59	0.02	0.8	0.376
T1/PD		0.42^{^b}	35.1^{^b}	<0.001^{^b}		0.41^{^b}	34.0^{^b}	<0.001^{^b}
Group		0.15^{^b}	17.3^{^b}	<0.001^{^b}		0.15^{^b}	16.8^{^b}	<0.001^{^b}
Group × BP_ND		0.06^{^b}	7.3^{^b}	0.010^{^b}		0.05^{^b}	5.8^{^b}	0.020^{^b}
Group × T1/PD		0.02	2.0	0.168		0.01	0.7	0.398
Precentral L
BP_ND	0.38	0.00	0.0	0.925	0.40	0.00	0.0	0.925
T1/PD		0.36^{^b}	27.3^{^b}	<0.001^{^b}		0.40^{^b}	31.3^{^b}	<0.001^{^b}
Group		0.06^{^b}	4.8^{^b}	0.033^{^b}		0.04	3.7	0.061
Group × BP_ND		0.02	1.4	0.249		0.02	1.4	0.246
Group × T1/PD		0.00	0.2	0.650		0.00	0.0	0.828
MTG L
BP_ND	0.45	0.12^{^b}	6.5^{^b}	0.014^{^b}	0.45	0.12^{^b}	6.5^{^b}	0.014^{^b}
T1/PD		0.34^{^b}	30.0^{^b}	<0.001^{^b}		0.35^{^b}	31.0^{^b}	<0.001^{^b}
Group		0.03	2.6	0.116		0.03	2.8	0.098
Group × BP_ND		0.01	0.5	0.471		0.01	0.5	0.505
Group × T1/PD		0.01	0.9	0.354		0.01	0.6	0.431
Gray matter increases in patients compared with controls
Angular gyrus L
BP_ND	0.56	0.32^{^b}	22.7^{^b}	<0.001^{^b}	0.61	0.32^{^b}	22.7^{^b}	<0.001^{^b}
T1/PD		0.22^{^b}	22.0^{^b}	<0.001^{^b}		0.28^{^b}	34.0^{^b}	<0.001^{^b}
Group		0.06^{^b}	6.4^{^b}	0.015^{^b}		0.04^{^b}	4.6^{^b}	0.038^{^b}
Group × BP_ND		0.00	0.0	0.899		0.01	0.6	0.439
Group × T1/PD		0.01	1.5	0.225		0.01	0.6	0.430
Cuneus R
BP_ND	0.81	0.70^{^b}	114.0^{^b}	<0.001^{^b}	0.87	0.70^{^b}	114.0^{^b}	<0.001^{^b}
T1/PD		0.12^{^b}	33.7^{^b}	<0.001^{^b}		0.17^{^b}	65.6^{^b}	<0.001^{^b}
Group		0.00	1.0	0.324		0.00	1.1	0.298
Group × BP_ND		0.00	0.9	0.358		0.01	2.0	0.160
Group × T1/PD		0.00	0.1	0.794		0.00	0.1	0.795
Postcentral gyrus R
BP_ND	0.40	0.22^{^b}	13.6^{^b}	0.001^{^b}	0.47	0.22^{^b}	13.6^{^b}	0.001^{^b}
T1/PD		0.18^{^b}	14.6^{^b}	<0.001^{^b}		0.24^{^b}	20.7^{^b}	<0.001^{^b}
Group		0.05^{^b}	4.5^{^b}	0.039^{^b}		0.04	3.7	0.059
Group × BP_ND		0.01	0.5	0.491		0.01	0.6	0.447
Group × T1/PD		0.01	0.4	0.531		0.03	2.4	0.130

↵^aGMV served as the dependent variable; flumazenil BP_ND, T1 time (water content) or proton density (PD), group (patients or controls), and the interaction terms served as the explanatory variables in the multiple regression analysis. L, Left; R, right.
↵^bSignificant with cluster-level correction across the whole brain at p < 0.05.