Table 2.

Functional GL-dSAC properties

+NBQX/AP5/GBZ
Cell-attached recordings
    Spontaneous firing rate (Hz)5.7 ± 5.2 (0.24–8.5) (10)6.5 ± 6.3 (0.0–11.1) (10)
    Spontaneous firing CVISI0.46 ± 0.45 (0.13–0.70) (10)0.21 ± 0.22 (0.08–0.20) (10)
Whole-cell recordings
    Spontaneous firing rate (Hz)8.3 ± 5.6 (3.9–12.2) (33)8.2 ± 4.1 (6.3–11.5) (6)
    Spontaneous firing CVISI0.19 ± 0.21 (0.08–0.21) (32)0.09 ± 0.07 (0.04–0.11) (6)
    Vm,ISI (mV)−54.5 ± 2.9 (−56.0 to −52.3) (33)−54.4 ± 4.4 (−57.2 to −51.1) (6)
sEPSC properties (Cs-internal)
    Frequency (Hz)10.0 ± 5.4 (6.3–12.1) (16)—
    Amplitude (pA)32.2 ± 8.2 (27.1–34.5) (16)—
    20–80% rise time (ms)0.42 ± 0.05 (0.39–0.47) (16)—
    Decay constant (ms)2.8 ± 1.0 (2.3–3.0) (16)—
sIPSC properties (Cs-internal)
    Frequency (Hz)12.8 ± 5.2 (8.7–16.9) (16)—
    Amplitude (pA)38.6 ± 8.0 (32.4–45.4) (16)—
    20–80% rise time (ms)0.82 ± 0.11 (0.74–0.90) (16)—
    Decay constant (ms)7.7 ± 1.3 (6.9–8.1) (16)—
    Input resistance (MΩ)551.6 ± 193.8 (410.4–702.5) (18)429.0 ± 110.8 (355.4–478.3) (6)
    Membrane time constant (ms)25.8 ± 7.2 (21.4–30.6) (18)22.0 ± 5.0 (18.6–23.8) (6)
    Membrane capacitance (pF)48.6 ± 10.2 (43.1–54.4) (18)52.0 ± 7.8 (47.1–55.2) (6)
    Sag amplitude (mV)10.0 ± 5.5 (5.9–12.9) (17)7.7 ± 6.4 (4.4–9.7) (6)
Action potential properties
    Threshold (mV)−45.0 ± 4.0 (−48.1 to −42.8) (20)−43.6 ± 7.8 (−49.1 to −37.5) (6)
    Amplitude (mV)73.6 ± 5.3 (71.7–78.2) (20)71.2 ± 2.7 (69.7–72.5) (6)
    Width (ms)0.67 ± 0.14 (0.60–0.80) (20)0.60 ± 0.09 (0.53–0.68) (6)
    Rising slope (mV/ms)253.0 ± 41.8 (218.3–277.7) (20)247.2 ± 38.6 (236.5–260.8) (6)
    Falling slope (mV/ms)−121.2 ± 31.0 (−144.3 to −98.0) (20)−132.2 ± 19.0 (−141.3 to −123.8) (6)
    Afterhyperpolarization (mV)17.5 ± 6.1 (13.2–21.8) (20)15.3 ± 5.0 (11.2–19.2) (6)
    Firing rate current gain (Hz/pA)0.59 ± 0.27 (0.40–0.68) (20)0.53 ± 0.16 (0.46–0.61) (6)

  • Values are shown as mean ± SD (Q1 − Q3) (n).