Effects of potassium stimulation on extracellular levels of neurotransmitters and metabolites
| Analyte | Basal levels (nm) | Phenotype effect on basal | Levels during stimulation (nm) | Main effect of stimulation | Phenotype × stimulation |
|---|---|---|---|---|---|
| Acetylcholine | |||||
| GTs | 312.93 ± 46.25 | n.s. | 992.89 ± 161.90 | F(1,9) = 47.66, p < 0.001 | F(1,9) = 5.92, p = 0.038 |
| STs | 328.59 ± 93.17 | 654.19 ± 116.68 | |||
| Choline | |||||
| GTs | 3620.77 ± 349.77 | n.s. | 4271.18 ± 527.00 | F(1,9) = 3.49, p = 0.10 | F(1,9) = 0.01, p = 0.98 |
| STs | 4540.33 ± 1608.44 | 5173.66 ± 1788.80 | |||
| Adenosine | |||||
| GTs | 88.96 ± 19.56 | n.s. | 433.95 ± 87.78 | F(1,9) = 25.91, p = 0.001 | F(1,9) = 8.29, p = 0.018 |
| STs | 58.16 ± 17.72 | 153.85 ± 45.03 | |||
| GABA | |||||
| GTs | 190.23 ± 61.07 | n.s. | 4649.34 ± 747.17 | F(1,9) = 27.36, p = 0.001 | F(1,9) = 0.26, p = 0.62 |
| STs | 534.50 ± 247.99 | 4198.82 ± 1659.85 | |||
| Glutamate | |||||
| GTs | 9918.11 ± 3578.66 | n.s. | 26346.11 ± 6299.28 | F(1,9) = 25.14, p = 0.001 | F(1,9) = 0.25, p = 0.63 |
| STs | 17595.26 ± 5371.42 | 37649.19 ± 9947.55 | |||
| Norepinephrine | |||||
| GTs | 5.87 ± 2.87 | n.s. | 27.90 ± 6.01 | F(1,9) = 21.47, p = 0.001 | F(1,9) = 0.54, p = 0.48 |
| STs | 13.69 ± 6.55 | 30.34 ± 7.33 | |||
| Serotonin | |||||
| GTs | 8.98 ± 0.46 | n.s. | 36.18 ± 9.91 | F(1,9) = 14.48, p = 0.004 | F(1,9) = 1.00, p = 0.34 |
| STs | 8.12 ± 2.46 | 24.00 ± 6.59 | |||
| Dopamine | |||||
| GTs | 5.41 ± 2.09 | n.s. | 18.25 ± 5.96 | F(1,9) = 23.26, p = 0.001 | F(1,9) = 0.13, p = 0.73 |
| STs | 8.63 ± 2.83 | 23.52 ± 5.46 |
Values were corrected for in vitro probe recovery rates.