Dendritic recordings during two-pathway pairing induced LTP in dorsal and ventral CA1 neuronsa
| Parameter | Dorsal | Ventral | p value | t value |
|---|---|---|---|---|
| Initial SC EPSP amplitude (mV) | 4.4 ± 0.46 | 4.4 ± 0.68 | 0.7 | 0.22 |
| Initial TA EPSP amplitude (mV) | 3.6 ± 0.4 | 4 ± 0.44 | 0.45 | 0.79 |
| 0 ms protocol depolarization area (mV × s) | 46.8 ± 6.8 | 75.6 ± 8.2 | 0.004** | 2.68 |
| 0 ms protocol plateau duration (ms) | 42.6 ± 7.6 | 91.8 ± 12.1 | 0.006** | 3.14 |
| 0 ms protocol SC pathway LTP (%) | 313 ± 57.1 | 331.4 ± 62 | 0.83 | 0.37 |
| 0 ms protocol TA pathway LTP (%) | 172.3 ± 18.7 | 183.5 ± 39.5 | 0.8 | 0.1 |
| 100 ms protocol depolarization area (mV × s) | 48.01 ± 4.5 | 80.23 ± 11.7 | 0.006** | 2.25 |
| 100 ms protocol plateau duration (ms) | 33.9 ± 3.7 | 78.5 ± 11.8 | 0.004** | 0.15 |
| 100 ms protocol SC pathway LTP (%) | 195 ± 14.2 | 440 ± 102.4 | 0.03* | 0.1 |
| 100 ms protocol TA pathway LTP (%) | 103.1 ± 8.4 | 183.1 ± 36.1 | 0.055 | 0.1 |
↵aThe amplitude of the initial EPSPs was similar for dorsal and ventral neurons. The depolarization areas and the plateau durations during TBP trains were significantly different for both 0 ms and 100 ms pairing protocols between dorsal and ventral neurons. LTP at the SC inputs to dorsal and ventral neurons was similar for 0 ms protocol but was different for the 100 ms protocol. LTP at the TA inputs to dorsal and ventral neurons was similar for both the 0 ms and 100 ms protocols.
↵*p < 0.05;
↵**p < 0.01; unpaired t test.