Summary of pharmacological results of GluN2B WT and mutants in X. laevis oocytes
| Glu, EC50, μM (nH, n) | Gly, EC50, μM (nH, n) | Mg2+, IC50, μM (nH, n) | Proton, IpH6.8/IpH7.6% (n) | |
|---|---|---|---|---|
| WT 2B | 1.3 ± 0.14 (1.1, 15) | 0.36 ± 0.02 (1.2, 12) | 28 ± 3.7 (0.92, 12) | 21 ± 1.6 (12) |
| S1413L | 1.3 ± 0.16 (1.0, 10) | 0.36 ± 0.06 (1.4, 6) | 20 ± 2.2 (0.91, 7) | 19 ± 0.33 (6) |
| L1422F | 2.1 ± 0.15 (1.2, 8)* | 0.43 ± 0.02 (1.4, 9) | 28 ± 3.0 (0.92, 6) | 17 ± 1.2 (6) |
| S1450F | 1.3 ± 0.10 (1.1, 6) | 0.25 ± 0.02 (1.3, 6)* | 31 ± 4.1 (0.86, 8) | 23 ± 1.7 (6) |
Data are shown as mean ± SEM.
nH, Hill slope.
↵*p < 0.05, one way ANOVA, Bonferroni's multiple-comparisons test.