Cell types | Heritability | Chronological age | Epigenetic age acceleration | Global white-matter tract integrity | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotypic correlation | Phenotypic correlation | Genetic correlation | Environmental correlation | Phenotypic correlation | Genetic correlation | Environmental correlation | ||||||||||||||
h2 | p | FDR | ρ | p | FDR | ρ | p | FDR | ρ | p | ρ | p | ρ | p | FDR | ρ | p | ρ | p | |
Naive CD8 T | 0.628* | 5.45E-15* | 1.91E-14* | −0.580* | 4.43E-67* | 3.10E-66* | −0.146* | 9.17E-04* | 2.14E-03* | 0.010 | 0.950 | −0.312* | 0.014* | 0.091 | 0.111 | 0.155 | — | — | — | — |
CD4 T | 0.359* | 2.80E-06* | 2.80E-06* | −0.117* | 3.27E-03* | 5.72E-03* | −0.164* | 1.05E-04* | 7.35E-04* | −0.059 | 0.780 | −0.219* | 0.029* | 0.105* | 0.043* | 0.086* | 0.135 | 0.521 | 0.085 | 0.565 |
Granulocytes | 0.519* | 1.61E-11* | 2.82E-11* | 0.015 | 0.712 | 0.712 | 0.010 | 0.814 | 0.814 | — | — | — | — | −0.170* | 1.29E-03* | 9.03E-03* | −0.292 | 0.125 | −0.049 | 0.758 |
Monocytes | 0.394* | 6.00E-07* | 7.00E-07* | 0.072 | 0.072 | 0.101 | 0.046 | 0.274 | 0.320 | — | — | — | — | −0.024 | 0.658 | 0.658 | — | — | — | — |
Natural killer | 0.656* | 3.27E-24* | 2.29E-23* | 0.342* | 1.49E-23* | 5.22E-23* | 0.053 | 0.214 | 0.300 | — | — | — | — | 0.116* | 0.026* | 0.086* | 0.214 | 0.160 | −0.010 | 0.952 |
Plasmablast | 0.512* | 1.97E-12* | 4.60E-12* | 0.016 | 0.683 | 0.712 | 0.066 | 0.124 | 0.217 | — | — | — | — | −0.108* | 0.049* | 0.086* | −0.264 | 0.168 | 0.044 | 0.780 |
CD8 + CD28-CD45RA-T | 0.410* | 1.00E-07* | 1.40E-07* | 0.306* | 9.06E-15* | 2.11E-14* | 0.149* | 4.02E-04* | 1.41E-03* | 0.193 | 0.339 | 0.125 | 0.206 | −0.045 | 0.398 | 0.464 | — | — | — | — |
↵aAn FDR correction was applied across the 7 cell types considered. Phenotypic correlations between cell abundances and epigenetic age acceleration or global white matter tract integrity were decomposed into genetic and environmental influences when phenotypic correlations p < 0.05. No decomposition was undertaken for phenotypic correlations with chronological age as this is not heritable.
↵*p < 0.05.