CNS Phenotypes of aged APP family KO mice
| Genotype | Phenotype (aged mice) | Status | Reference |
|---|---|---|---|
| APP−/− | Spine density | Reduced | Tyan et al. (2012) |
| LTP | Impaired | Seabrook et al. (1999); Ring et al. (2007); Tyan et al. (2012) | |
| Fiber volley/EPSP slope | Unchanged | Tyan et al. (2012) | |
| Paired-pulse facilitation | Unchanged | Tyan et al. (2012) | |
| mEPSC frequency | Not determined | ||
| mEPSC amplitude | Not determined | ||
| APLP1−/− | Spine density | Reduced | This article |
| LTP | Unchanged | This article | |
| Fiber volley/EPSP slope | Reduced | This article | |
| Paired-pulse facilitation | Unchanged | This article | |
| mEPSC frequency | Reduced | This article | |
| mEPSC amplitude | Unchanged | This article | |
| APLP2−/− | Spine density | Unchanged | Midthune et al. (2012) |
| LTP | Unchanged | Weyer et al. (2011); Midthune et al. (2012) | |
| Fiber volley/EPSP slope | Unchanged | Weyer et al. (2011); Midthune et al. (2012) | |
| Paired-pulse facilitation | Unchanged | Midthune et al. (2012) | |
| mEPSC frequency | Not determined | ||
| mEPSC amplitude | Not determined |
One-year-old APP, APLP1, and APLP2 KO mice have been analyzed by different groups. For APLP2, no CNS phenotype has been observed so far. APP KO mice show reduced spine density and impaired LTP. APLP1 KO mice reveal reduced spine density, reduced fiber volley/EPSP slope, and reduced mEPSC frequency.