Table 2.

Basic properties of the hyperpolarization-activated current (Ih) in WT and Fmr1 KO LSO neuronsa

Current (nA) at −95 mVMaximum half-activation (mV)
P21
    WT (n = 10)2.64 ± 0.13−71.02 ± 1.09
    Fmr1 KO (n = 12)2.47 ± 0.22−70.54 ± 1.47
    p0.530.79
  • aVoltage-clamp recordings were obtained in the presence of the following (in mm): 1 3,4-diaminopyridine, 10 TEA-Cl, 0.2 BaCl2, 0.001 TTX, 0.05 NiCl2, 0.1 CdCl2, 0.01 DNQX, 0.025 dl-AP5, and 0.001 strychnine, to block other voltage-gated conductances.