Table 1.

Basic membrane properties of LSO neurons in WT and Fmr1 KO micea

Peak Rin (mΩ)SS Rin (mΩ)RMP (mV)τ (ms)
P8
    WT (n = 17)189.4 ± 21.5101.3 ± 11.1−57.40 ± 1.017.28 ± 1.87
    Fmr1 KO (n = 16)217.1 ± 24.192.50 ± 7.33−61.08 ± 1.121.16 ± 2.12
    p0.55>0.990.0240.014
P14
    WT (n = 16)70.42 ± 7.4137.41 ± 5.2−49.82 ± 0.83.95 ± 0.51
    Fmr1 KO (n = 15)75.70 ± 14.2443.20 ± 7.4−50.54 ± 1.43.96 ± 0.90
    p>0.99>0.99>0.99>0.99
P21
    WT (n = 39)42.75 ± 1.522.04 ± 0.63−50.31 ± 0.522.0 ± 0.14
    Fmr1 KO (n = 20)54.03 ± 5.028.54 ± 2.91−50.06 ± 0.61.95 ± 0.22
    p>0.99>0.99>0.99>0.99
  • aInput resistance (Rin) was measured at the peak and the steady state (SS) response to a −100 pA current pulse. RMP, Resting membrane potential. p values: two-way ANOVA followed by Bonferroni post-tests.