Table 2.

Performance on a battery of sensorimotor tests of adult Ctcf CKO mice and controls

Test	Control (mean ± SEM)	Ctcf CKO (mean ± SEM)	t statistic (df = 17)	p-value	Significance
60° inclined screen	30.40 ± 5.30 s	27.10 ± 6.96 s	0.382	0.707	NS
90° inclined screen	32.90 ± 5.27 s	30.57 ± 5.39 s	0.308	0.762	NS
180° inverted screen	58.85 ± 0.77 s	53.67 ± 3.13 s	1.688	0.110	NS
Walking initiation	3.18 ± 0.83 s	7.40 ± 3.24 s	−1.322	0.203	NS
Ledge	55.60 ± 2.94 s	38.53 ± 5.28 s	2.904	0.010	^*
Elevated platform	51.00 ± 3.49 s	29.77 ± 4.43 s	3.804	0.001	^**
Elevated pole	46.47 ± 7.55 s	77.11 ± 11.68 s	−2.250	0.038	^*

Adult Ctcf CKO mice have impaired balance and fine motor coordination in tests of sensorimotor function. Behavioral performance of the adult (3–4 months old) Ctcf CKO (n = 9) and control (n = 10) mice was evaluated on the battery of sensorimotor tests. The first column lists the behavioral test conducted. The second and third columns list the means ± SEM for controls and Ctcf CKO mice, respectively. The fourth column lists the p-value obtained for Student's t test using t₍₁₇₎ degrees of freedom (df). The last column indicates the degree of statistical significance. Time to fall from a mesh screen oriented at 60°, 90°, and 180° (inverted) was similar between Ctcf CKO and control mice. Animals of both genotypes had similar latency to initiate walking. Ctcf CKO mice had difficulty with: balancing on a narrow ledge (t₍₁₇₎ *p = 0.010); balancing on a small, circular, elevated platform (t₍₁₇₎ **p = 0.001), and climbing down an elevated pole (t₍₁₇₎ *p = 0.038).
NS, Not significant.
↵* p < 0.05,
↵* *p < 0.01.